Study on the molecular mechanism controlled by SPACIA1, which associated with synoviocyte proliferation.
| Project/Area Number |
24791009
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
KOMATSU RIE 聖マリアンナ医科大学, 医学(系)研究科(研究院), 研究技術員 (80517475)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 滑膜炎 / 細胞増殖 / SPACIA1 |
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| Research Abstract |
SPACIA1 is a novel gene associated with abnormal synovial proliferation which is one of the major characteristics of rheumatoid arthritis (RA). In this study, we aimed to a precise understanding of the molecular mechanisms behind this process. We analyzed constituents of purified SPACIA1 protein complex using shotgun proteomics. We identified CDK6, one of functional genes at G1 phase, which gene expression is regulated by SPACIA1 in mRNA turnover. CDK6 knockdown by its siRNA inhibited the proliferation of cultured RA synovial fibroblasts. These results suggested that CDK6 is functionally involved in RA synoviocyte proliferation. Specific inhibition of CDK6 may be a useful therapeutic strategy for RA.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Analysis of a Core Promoter Context of Synoviocyte Proliferation-Associated in Collagen Induced Arthritis 1 (SPACIA1) Gene Associated with Synovitis2012
Author(s)
Fujii R, Komatsu R, Sato T, Yagishita N, Araya N, Aratani S, Nishikawa H, Yamano Y, Yudoh K, Beppu M, Nishioka K, Nakajima T
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Journal Title
J St. Marianna Univ
Volume: 40
Pages: 51-56
Related Report
Peer Reviewed
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[Presentation] Analysis of core promoter context of SPACIA1/SAAL1 gene, which is related to synovitis2012
Author(s)
Ryoji Fujii, Rie Komatsu, Tomoo Sato, Naoko Yagishita, Satoko Aratani, Koji Konomi, Hiroyuki Aono, Yoshihisa Yamano, Moroe Beppu, Kazuo Yudoh, Kusuki Nishioka, Toshihiro Nakajima
Organizer
第56回日本リウマチ学会
Place of Presentation
東京都(グランドプリンスホテル新高輪)
Year and Date
2012-04-26
Related Report
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