Respiratory allergy to booklice, a common household small insect

• Project/Area Number: 24791017
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
• Principal Investigator: FUKUTOMI Yuma 独立行政法人国立病院機構(相模原病院臨床研究センター), 診断・治療薬開発研究室, 室長 (30463110)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: アレルギー・ぜんそく / 昆虫

Outline of Final Research Achievements

Distribution of booklice in houses in Kanto region was studied. More booklice were found in sunless bedroom in apartment houses, especially when the room contained Japanese tatami mats. Association between living environment and sensitization profile among patients with asthma has also been examined using structured questionnaire. Asthmatic patients were significantly more likely to be sensitized to booklice when their bedroom contained tatami mats and/or carpets. These finding indicate that using tatami mat/carpet in bedroom is strong risk factor for the development of allergy to booklice.

Research Products

• [Journal Article] Frequent episodes of adult soybean allergy during and following the pollen season (2015)
  • Author(s): Minami T, Fukutomi Y, Saito A, Sekiya K, Tsuburai T, Taniguchi M, Akiyama K.
  • Journal Title: J Allergy Clin Immunol Pract Volume: 3(3): Issue: 3 Pages: 441-442
  • DOI: 10.1016/j.jaip.2014.11.024
  • Peer Reviewed
• [Journal Article] IgE Abs to Der p 1 and Der p 2 as diagnostic markers of house dust mite allergy as defined by a bronchoprovocation test (2015)
  • Author(s): Minami T, Fukutomi Y, Lidholm J, Yasueda H, Saito A, Sekiya K, Tsuburai T, Maeda Y, Mori A, Taniguchi M, Hasegawa M, Akiyama K
  • Journal Title: Allergology International Volume: 64 Issue: 1 Pages: 90-95
  • DOI: 10.1016/j.alit.2014.08.004
  • NAID: 130004873139
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Japanese Society of Allergology task force report on standardization of house dust mite allergen vaccines - Secondary publication (2015)
  • Author(s): Takai T, Okamoto Y, Okubo K, Nagata M, Sakaguchi M, Fukutomi Y, Saito A, Yasueda H, Masuyama K
  • Journal Title: Allergology International Volume: 64 Issue: 2 Pages: 181-186
  • DOI: 10.1016/j.alit.2015.01.005
  • NAID: 130005290283
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] A survey on the distribution of booklice, other allergenic arthropods, and fungi in houses in Tokyo (2014)
  • Author(s): Yuji Kawakami, Kazuhiro Hashimoto, Yuma Fukutomi, Masami Taniguchi, Akemi Saito, Kazuo Akiyama
  • Journal Title: Urban Pest Management Volume: 4 (2) Pages: 65-77
  • NAID: 110009878584
  • Peer Reviewed
• [Journal Article] Epidemiological link between wheat allergy and exposure to hydrolyzed wheat protein in facial soap. (2014)
  • Author(s): Fukutomi Y, Taniguchi M, Nakamura H, Akiyama K.
  • Journal Title: Allergy. Volume: 69(10) Issue: 10 Pages: 1405-1411
  • DOI: 10.1111/all.12481
  • Peer Reviewed
• [Journal Article] Oral Mite Anaphylaxis Caused by Mite-Contaminated Okonomiyaki/ Pancake-Mix in Japan: 8 Case Reports and a Review of 28 Reported Cases (2014)
  • Author(s): Takahashi K, Taniguchi M, Fukutomi Y, Sekiya K, Watai K, Mitsui C, Tanimoto H, Oshikata C, Tsuburai T, Tsurikisawa N, Minoguchi K, Nakajima H, Akiyama K.
  • Journal Title: Allergology International Volume: 63 Issue: 1 Pages: 51-56
  • DOI: 10.2332/allergolint.13-OA-0575
  • NAID: 130004873102
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Tissue transglutaminase generates deamidated epitopes on gluten, increasing reactivity with hydrolyzed wheat protein-sensitized IgE (2013)
  • Author(s): Nakamura R, Nakamura R, Sakai S, Adachi R, Hachisuka A, Urisu A, Fukutomi Y, Teshima R.
  • Journal Title: J. Allergy Clin. Immunol. Volume: 132 Issue: 6 Pages: 1436
  • DOI: 10.1016/j.jaci.2013.07.017
  • Peer Reviewed
• [Journal Article] Age-Specific Characteristics of Inpatients with Severe Asthma Exacerbation (2013)
  • Author(s): Sekiya K, Taniguchi M, Fukutomi Y, Watai K, Minami T, Hayashi H, Ito J, Tanimoto H, Oshikata C, Tsurikisawa N, Tsuburai T, Hasegawa M, Akiyama K.
  • Journal Title: Allergology International Volume: 62 Issue: 3 Pages: 331-336
  • DOI: 10.2332/allergolint.12-OA-0525
  • NAID: 130004477187
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Immunization of Rabbits with Nematode <i>Ascaris lumbricoides</i> Antigens Induces Antibodies Cross-Reactive to House Dust Mite <i>Dermatophagoides farinae</i> Antigens (2013)
  • Author(s): Nakazawa T, Khan AF, Yasueda H, Saito A, Fukutomi Y, Takai T, Zaman K, Yunus M, Takeuchi H, Iwata T, Akiyama K.
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 77 Issue: 1 Pages: 145-150
  • DOI: 10.1271/bbb.120626
  • NAID: 10031164704
  • ISSN: 0916-8451, 1347-6947
  • Peer Reviewed
• [Journal Article] Evaluation of allergenicity of acid-hydrolyzed wheat protein using an in vitro elicitation test (2013)
  • Author(s): Nakamura, R., Nakamura, R., Adachi, R., Itagaki, Y., Fukutomi, Y., Teshima, R
  • Journal Title: nternational Archives of Allergy and Immunology Volume: 160 Issue: 3 Pages: 259
  • DOI: 10.1159/000341671
  • Peer Reviewed
• [Journal Article] Delayed anaphylactic reaction to mammalian meat (2012)
  • Author(s): Sekiya K, Fukutomi Y, Nakazawa T, Taniguchi M, Akiyama K
  • Journal Title: J Investig Allergol Clin Immunol Volume: 22(6) Pages: 446-447
  • Peer Reviewed
• [Journal Article] Sensitization to acid-hydrolyzed wheat protein by transdermal administration to BALB/c mice, and comparison with gluten (2012)
  • Author(s): Adachi R., Nakamura R., Sakai S., Fukutomi Y., Teshima R.
  • Journal Title: Allergy Volume: 67 Issue: 11 Pages: 1392
  • DOI: 10.1111/all.12018
  • Peer Reviewed
• [Journal Article] Non Occupational Chronic Hypersensitivity Pneumonitis due to <i>Aspergillus fumigatus</i> on Leaky Walls (2012)
  • Author(s): Mitsui C, Taniguchi M, Fukutomi Y, Saito A, Kawakami Y, Mori A, Akiyama K.
  • Journal Title: Allergology International Volume: 61 Issue: 3 Pages: 501-502
  • DOI: 10.2332/allergolint.12-LE-0421
  • NAID: 130004477153
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] The prevalence of rhinitis and its association with smoking and obesity in a nationwide survey of Japanese adults. (2012)
  • Author(s): Konno S, Hizawa N, Fukutomi Y, Taniguchi M, Kawagishi Y, Okada C, Tanimoto Y, Takahashi K, Akasawa A, Akiyama K, Nishimura M.
  • Journal Title: Allergy. Volume: 67(5): Issue: 5 Pages: 653-60
  • DOI: 10.1111/j.1398-9995.2012.02793.x
  • Peer Reviewed
• [Journal Article] Clinical relevance of IgE to recombinant Gly m 4 in the diagnosis of adult soybean allergy (2012)
  • Author(s): Fukutomi.Y
  • Journal Title: J.Allergy Clin.Immunol. Volume: Vol.129 Issue: 3 Pages: 860-863
  • DOI: 10.1016/j.jaci.2012.01.031
  • Peer Reviewed
• [Journal Article] Allergenicity and cross-reactivity of booklice (Liposcelis bostrichophila) : a common household insect pest in Japan (2012)
  • Author(s): Fukutomi.Y
  • Journal Title: Int.Arch.Allergy Immunol. Volume: Vol.157 Issue: 4 Pages: 339-348
  • DOI: 10.1159/000329853
  • Peer Reviewed
• [Journal Article] Obesity and aspirin intolerance are risk factors for difficult-to-treat asthma in Japanese non-atopic women (2012)
  • Author(s): Fukutomi.Y
  • Journal Title: Clin.Exp.Allergy Volume: Vol.42 Issue: 5 Pages: 738-746
  • DOI: 10.1111/j.1365-2222.2011.03880.x
  • Peer Reviewed
• [Journal Article] Association between body mass index and asthma among Japanese adult : risk within normal weight range (2012)
  • Author(s): Fukutomi.Y
  • Journal Title: Int.Arch.Allergy Immunol. Volume: Vol.157 Issue: 3 Pages: 281-287
  • DOI: 10.1159/000327555
  • Peer Reviewed
• [Presentation] Risk factors for the development of wheat allergy among individuals who have used a facial soap containing hydrolyzed wheat protein: case-control study. (2014)
  • Author(s): Fukutomi Y., Kishikawa R., Sugiyama A., Minami T., Taniguchi M., Akiyama K.
  • Organizer: European Academy of Allergy and Clinical Immunology Congress 2014.
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2014-06-07 – 2014-06-11
• [Presentation] 室内塵中に最も普遍的に認められる微小昆虫・ヒラタチャタテの吸入性抗原としての独自性と交差性 (2012)
  • Author(s): 福冨友馬 川上裕司 谷口正実 斎藤明美 福田安住 安枝 浩 中澤卓也 長谷川眞紀 秋山一男
  • Organizer: 第37回KRC神奈川呼吸カンファレンス
  • Place of Presentation: 横浜
• [Presentation] 環境中の吸入性昆虫アレルゲン
  • Author(s): 福冨友馬
  • Organizer: 第4回 横浜環境アレルギー研究
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 吸入性アレルゲン：最近の話題
  • Author(s): 福冨友馬
  • Organizer: 第44回 日本・職業環境アレルギー学会 総会
  • Place of Presentation: 相模原
  • Invited
• [Book] 吸入性アレルゲンの同定と対策 (2014)
  • Author(s): 福冨友馬 谷口正実 (監修)
  • Total Pages: 64
  • Publisher: メディカルレビュー