• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Live-imaging of Pneumococci and immune-cells in lung.

Research Project

Project/Area Number 24791024
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionYamaguchi University

Principal Investigator

OGINO Hidetaka  山口大学, 医学(系)研究科(研究院), 助教 (80589325)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords感染症 / 免疫細胞 / 免疫学 / 細菌学
Research Abstract

Pneumonia is the leading cause of death in children worldwide.
In the causing agent of pneumonia, Streptococcus pneumoniae is the major pathogenic bacterium. Pneumonia caused by bacteria can be treated with antibiotics. However antibiotic-resistant S. pneumoniae is appeared recently, and the antibiotic treatment is becoming difficult. For preventive measures to pneumonia, the vaccination is important.
In this study, we tried to uncover the nature of pneumococci and immune-cells at lung in living body with or without pneumococcal-vaccine. For live imaging at lung, we developed the brighter fluorescent pneumococci. The fluorescent pneumococci were colonized at pulmonary alveoli, and some were flown in the blood vessel. The fluorescent immune-cells is going to be injection into the pneumococci infected mouse, and the phagocytosis of pneumococci by immune-cells is going to be observed. In future, the effect of vaccination to the immunological response will be uncovered.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (9 results)

  • [Journal Article] Crucial role for CD69 in the pathogenesis of dextran sulphate sodium-induced colitis.2013

    • Author(s)
      Hasegawa A, Iwamura C, Kitajima M, Hashimoto K, Otsuyama K, Ogino H, Nakayama T and Shirai M.
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 6 Pages: e65494-e65494

    • DOI

      10.1371/journal.pone.0065494

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 腸炎の誘導におけるCD69の役割2014

    • Author(s)
      長谷川 明洋, 荻野 英賢, 大津山 賢一郎, 中山 俊憲, 白井 睦訓
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2013 Final Research Report
  • [Presentation] 腸炎の誘導におけるCD69の役割2014

    • Author(s)
      長谷川 明洋、荻野 英賢、大津山 賢一郎、中山 俊憲、白井 睦訓
    • Organizer
      第87回 日本細菌学会総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] アレルギー性炎症反応におけるリンパ球浸潤に関与する分子の探索2013

    • Author(s)
      長谷川 明洋, 荻野 英賢, 大津山 賢一郎, 中山 俊憲
    • Organizer
      第22回日本バイオイメージング学会学術集会
    • Place of Presentation
      東京大学(東京)
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺炎球菌高発現プロモーターの探索2013

    • Author(s)
      荻野 英賢, 長谷川 明洋, 大津山 賢一郎, 白井 睦訓
    • Organizer
      第66回日本細菌学会中国・四国支部総会
    • Place of Presentation
      広島国際大学呉キャンパス(呉)
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺炎球菌高発現プロモーターの探索2013

    • Author(s)
      荻野 英賢,長谷川 明洋,大津山 賢一郎,白井 睦訓
    • Organizer
      第66回 日本細菌学会中国・四国支部総会
    • Place of Presentation
      広島国際大学呉キャンパス(呉)
    • Related Report
      2013 Annual Research Report
  • [Presentation] アレルギー性炎症反応におけるリンパ球浸潤に関与する分子の探索2013

    • Author(s)
      長谷川明洋、荻野英賢、大津山賢一郎、中山俊憲
    • Organizer
      第22回 日本バイオイメージング学会学術集会
    • Place of Presentation
      東京大学(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Real-time Cellular Imaging of T Lymphocyte Accumulation in a Mouse Asthma Model2013

    • Author(s)
      Akihiro Hasegawa, Hidetaka Ogino, Mutsunori Shirai, Toshinori Nakayama
    • Organizer
      The 23rd CDB Meeting
    • Place of Presentation
      RIKEN CDB, Kobe(兵庫県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 腸炎の発症におけるCD69分子の役割2013

    • Author(s)
      長谷川明洋、荻野英賢、大津山賢一郎、中山俊憲、白井睦訓
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 酢酸菌高温耐性株における細胞形態形成機構の解析2012

    • Author(s)
      荻野英賢,長谷川明洋,大津山賢一郎,白井睦訓
    • Organizer
      第65回 日本細菌学会中国・四国支部総会
    • Place of Presentation
      徳島大学 長井記念ホール(徳島県)
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi