| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Considering the limitations of the currently available antifungals, emergence of multiantifungal resistance poses a serious concern in clinical settings. Recent surveillance data have revealed an increased number of Candida glabrata clinical isolates that display resistance to not only azoles but also echinocandins. In this study, we discovered that a single amino acid substitution in gene X confers multiantifungal resistance without affecting virulence in C. glabrata and revealed molecular mechanisms of this phenomenon.
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