Elucidation of multiantifungal resistance mechanisms in pathogenic fungi and evaluation of clinical significance
| Project/Area Number |
24791027
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
MIYAZAKI Taiga 長崎大学, 医歯薬学総合研究科(医学系), 講師 (60448496)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 薬剤耐性 |
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| Outline of Final Research Achievements |
Considering the limitations of the currently available antifungals, emergence of multiantifungal resistance poses a serious concern in clinical settings. Recent surveillance data have revealed an increased number of Candida glabrata clinical isolates that display resistance to not only azoles but also echinocandins. In this study, we discovered that a single amino acid substitution in gene X confers multiantifungal resistance without affecting virulence in C. glabrata and revealed molecular mechanisms of this phenomenon.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Contribution of the Slt2-regulated transcription factors to echinocandin tolerance in Candida glabrata.2014
Author(s)
Nagayoshi Y, Miyazaki T, Minematsu A, Yamauchi S, Takazono T, Nakamura S, Imamura Y, Izumikawa K, Kakeya H, Yanagihara K, Kohno S.
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Journal Title
FEMS Yeast Research
Volume: 14
Pages: 1128-1131
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] The Heme-binding Protein Dap1 links Iron Homeostasis to Azole Resistance via the P450 Protein Erg11 in Candida glabrata.2013
Author(s)
Hosogaya N, Miyazaki T, Nagi M, Tanabe K, Minematsu A, Nagayoshi Y, Yamauchi S, Nakamura S, Imamura Y, Izumikawa K, Kakeya H, Yanagihara K, Miyazaki Y, Kugiyama K, Kohno S.,
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Journal Title
FEMS Yeast Research
Volume: (掲載決定)
Issue: 4
Pages: 411-421
DOI
Related Report
Peer Reviewed
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