| Project/Area Number |
24791035
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
AINAI Akira 国立感染症研究所, インフルエンザウイルス研究センター, 主任研究官 (10572133)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 合成二本鎖RNA / アジュバント / 経鼻インフルエンザワクチン / 感染症 |
|---|
| Research Abstract |
Synthetic double-stranded RNAs, TLR3 agonists, are known to be mucosal adjutant to induce virus-specific secretory IgA antibodies in intranasal vaccination against influenza virus infection. On the other hand, TLR7 agonists may be mucosal adjuvants for intranasal vaccination, since influenza viral RNAs are recognized by TLR7 in a natural infection with influenza virus. However, mucosal adjuvant activities of TLR7 agonists were inferior to those of TLR3 agonists.
At present, the mechanism for secretory IgA antibody induction by synthetic double-stranded RNAs as mucosal adjuvants is continuously investigated.
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