Analysis of chronic allergic inflammation using peripheral blood dendritic cells
| Project/Area Number |
24791040
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Chiba University |
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Principal Investigator |
INOUE YUZABURO 千葉大学, 医学部附属病院, 助教 (00456063)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アレルギー / 樹状細胞 / インフラマソーム / TSLP |
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| Research Abstract |
We analyzed differences of inflammasome activation or functions in myeloid dendritic cells (mDC) and plasmacytoid dendritic cells (pDC) in peripheral blood between allergic children and healthy controls. We found that LPS-induced caspase-1 activation was associated with decrease of TSLP receptor expression on mDC and increase of TSLP receptor on pDC, suggesting that increase of inflammasome activation might be associated with less Th2 induction and/or more Treg induction. In the patients who received rush oral immunotherapy for milk allergy, pDC was increased in peripheral blood, suggesting that pDCs might play a roll in the mechanisms of tolerance of food allergy.
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Report
(3 results)
Research Products
(12 results)
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[Presentation] Oral Immunotherapy for Milk Allergy Increases the Frequency of CD4+NKG2D+ T Cells, CD4+CD25-CD127- T Cells and Peripherally derived Tregs in Peripheral Blood2013
Author(s)
Inoue Y, Chiba K, Kato I, Morita Y, Nakano T, Yamaide A, Suzuki S, Arima T, Tomiita M, Hoshioka A, Shimojo N, Kohno Y
Organizer
Asia Pacific Congress of Asthma, Allergy, and Clinical Immunology 2013
Place of Presentation
Taipei, Taiwan
Related Report
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