Effect of TGF-beta 1 eluting graft on pulmonary circulation in congenital heart disease
| Project/Area Number |
24791067
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SAKATA Miho 徳島大学, 大学病院, 特任助教 (80532514)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 肺血管 / 肺高血圧 / TGF-β1 / 先天性心疾患 / 肺循環 / 平滑筋細胞 / TGF-β |
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| Outline of Final Research Achievements |
Hypoplastic pulmonary artery and pulmonary circulatory disturbance induce the poor prognosis in children with congenital heart disease. Pulmonary arterial hypertension shows the intima/media hyperplasia. These condition results in severe heart failure. In this study, we’d tried to invent the novel TGF-beta 1 eluting expanded polytetrafluoroethylene graft to prevent the pulmonary arterial pathological change. The administration of TGF-beta 1 inhibits the pulmonary smooth cell proliferation and migration. It did not make the pulmonary artery pressure decreased.
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Report
(4 results)
Research Products
(13 results)
