Effect of TGF-beta 1 eluting graft on pulmonary circulation in congenital heart disease

• Project/Area Number: 24791067
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: The University of Tokushima
• Principal Investigator: SAKATA Miho 徳島大学, 大学病院, 特任助教 (80532514)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 肺血管 / 肺高血圧 / TGF-β1 / 先天性心疾患 / 肺循環 / 平滑筋細胞 / TGF-β

Outline of Final Research Achievements

Hypoplastic pulmonary artery and pulmonary circulatory disturbance induce the poor prognosis in children with congenital heart disease. Pulmonary arterial hypertension shows the intima/media hyperplasia. These condition results in severe heart failure. In this study, we’d tried to invent the novel TGF-beta 1 eluting expanded polytetrafluoroethylene graft to prevent the pulmonary arterial pathological change. The administration of TGF-beta 1 inhibits the pulmonary smooth cell proliferation and migration. It did not make the pulmonary artery pressure decreased.

Research Products

• [Journal Article] Right ventricular myocardial deformation pattern with congenital heart disease associated with right ventricular pressure overload (2015)
  • Author(s): Hayabuchi Y, Sakata M, Kagami S.
  • Journal Title: Eur Heart J Cardivasc Imaging Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Assessment of the helical ventricular myocardial band using standard echocardiography. (2015)
  • Author(s): Hayabuchi Y, Sakata M, Kagami S.
  • Journal Title: Echocardiography Volume: 印刷中 Issue: 2 Pages: 310-318
  • DOI: 10.1111/echo.12624
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of Two-Component Ventricular Septum: Functional Differences in Systolic Deformation and Rotation Assessed by Speckle Tracking Imaging. (2014)
  • Author(s): Hayabuchi Y, Sakata M, Kagami S.
  • Journal Title: Echocardiography Volume: 印刷中 Issue: 7 Pages: 815-824
  • DOI: 10.1111/echo.12484
  • Peer Reviewed
• [Journal Article] Left Atrial Volume Change Throughout the Cardiac Cycle in Children With Congenital Heart Disease Associated With Increased Pulmonary Blood Flow : Evaluation Using a Novel Left Atrium-Tracking Method (2013)
  • Author(s): Sakata M, Hayabuchi Y, Inoue M, Onishi T, Kagami S
  • Journal Title: Pediatric Cardiology Volume: 34 Issue: 1 Pages: 105-111
  • DOI: 10.1007/s00246-012-0395-4
  • Peer Reviewed
• [Journal Article] Ratio of Early Diastolic Tricuspid Inflow to Tricuspid Lateral Annulus Velocity Reflects Pulmonary Regurgitation Severity but Not Right Ventricular Diastolic Function in Children With Repaired Tetralogy of Fallot (2013)
  • Author(s): Hayabuchi Y, Sakata M, Ohnishi T, Inoue M, Kagami S
  • Journal Title: Pediatric Cardiology Volume: 34 Issue: 5 Pages: 1112-1117
  • DOI: 10.1007/s00246-012-0612-1
  • Peer Reviewed
• [Presentation] 正常肺組織を犠牲とすることを前提としてコイル塞栓術を施行した両側肺全区域びまん性肺動静脈瘻 (2015)
  • Author(s): 早渕康信 坂田美穂 香美祥二
  • Organizer: 第26回日本Pediatric Interventional Cardiology学会
  • Place of Presentation: 大阪国際交流センター（大阪府大阪市）
  • Year and Date: 2015-01-22 – 2015-01-24
• [Presentation] 右室圧負荷を有する先天性心疾患症例では心室中隔の心筋進展性が低下する -DWSを用いた心室中隔のスティフネス測定- (2014)
  • Author(s): 坂田美穂 早渕康信 森一博 香美祥二
  • Organizer: 第25回日本心エコー図学会学術集会
  • Place of Presentation: 石川県立音楽堂 金沢市アートホール（石川県金沢市）
  • Year and Date: 2014-04-17 – 2014-04-19
• [Presentation] カテーテル治療後に出現し、摘出術を要したFibromyxoid excrescence of aortic valve (2014)
  • Author(s): 阪田美穂, 早渕康信, 香美祥二
  • Organizer: 第25回日本Pediatric Interventional Cardiology研究会
  • Place of Presentation: ブエナビスタ松本(長野県)
• [Presentation] 肺欝血・肺静脈拡大を反映する心エコー検査拡張能指標の検出－心室中隔欠損による左心前負荷増加群における検討－ (2013)
  • Author(s): 阪田美穂, 早渕康信, 香美祥二
  • Organizer: 第49回日本小児循環器学会総会・学術集会
  • Place of Presentation: 国立オリンピック記念青少年総合センター(東京都)
• [Presentation] 進行性に３枝ブロックを認め、ペースメーカー治療を要した新生児例 (2013)
  • Author(s): 阪田美穂, 早渕康信, 香美祥二, 菅野幹雄, 北市隆, 北川哲也
  • Organizer: 第18回日本小児心電学研究会
  • Place of Presentation: 宮崎県医師会館(宮崎県)
• [Presentation] 先天性心疾患小児症例におけるDual Doppler法を用いた拡張早期左室流入血流と僧帽弁輪運動の時相解析 (2012)
  • Author(s): 阪田美穂
  • Organizer: 第23回日本心エコー図学会学術学術集会
  • Place of Presentation: グランキューブ大阪(大阪府)
  • Invited
• [Presentation] Dual Doppler法を用いた拡張早期左室流入血流と僧帽弁輪運動の時相解析による左室拡張障害診断 (2012)
  • Author(s): 阪田美穂
  • Organizer: 第48回日本小児循環器学会総会・学術集会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Invited
• [Book] Mechanically Gated Channels and their Regulation (2012)
  • Author(s): Kamkin Andre
  • Total Pages: 429
  • Publisher: Springer