The new strategy of treatment of Kawasaki disease on the basis of gene expression in Kawasaki disease-like vasculitis mouse model

• Project/Area Number: 24791069
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Kyushu University
• Principal Investigator: NAGATA Hazumu 九州大学, 医学(系)研究科(研究院), 助教 (20570790)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 川崎病マウスモデル / サイトカイン / ケモカイン / 心エコー / 川崎病 / 血管炎 / 国際情報交換

Research Abstract

Our previous research demonstrated that the gene associated with cytokine or chemokine was overexpressed in mouse model of Kawasaki disease-like vasculitis. In the present research, the administration of anti IL-6 antibody and anti CCL2 antibody could not suppress the inflammation. These results suggested that several cytokine and chemokine were related to the occurrence of vasculitis. The cardiac function of mouse model decreased gradually. There was no relation between the degree of inflammation of vasculitis and the level of echogenicity of coronary artery. We should increase the number of case and modify the methods.

Research Products

• [Journal Article] Early progression of atherosclerosis in children with chronic infantile neurological cutaneous and articular syndrome (2014)
  • Author(s): Yamamura K, Takada H, Uike K, Nakashima Y, Hirata Y, Nagata H, Takimoto T, Ishimura M, Morihana E, Ohga S, Hara T
  • Journal Title: Rheumatology Volume: (Epub ahead of print)
• [Journal Article] Testicular sex cord-stromal tumor in a boy with 2q37 deletion syndrome (2014)
  • Author(s): Sakai Y, Souzaki R, Yamamoto H, Matsushita Y, Nagata H, Ishizaki Y, Torisu H, Oda Y, Taguchi T, Shaw CA, Hara T
  • Journal Title: BMC Med Genomics Volume: (Epub ahead of print)
• [Journal Article] Staphylococcal endocarditis as the first manifestation of heritable protein S deficiency in childhood (2014)
  • Author(s): Hoshina T, Nakashima Y, Sato D, Nanishi E, Nishio H, Nagata H, Yamamura K, Doi T, Shiokawa Y, Koga Y, Kang D, Ohga S, Hara T
  • Journal Title: J Infect Chemother Volume: (Epub ahead of print)
• [Journal Article] Systemic vascular phenotypes of Loeys-Dietz syndrome in a child carrying a de novo R381P mutation in TGFBR2 : a case report (2013)
  • Author(s): Uike K, Matsushita Y, Sakai Y, Togao O, Nagao M, Ishizaki Y, Nagata H, Yamamura K, Torisu H, Hara T
  • Journal Title: BMC Res Notes Volume: 6 Pages: 456-456
• [Journal Article] Development of Kawasaki disease in a patient with PFAPA (2013)
  • Author(s): Ninomiya T, Takada H, Nagatomo Y, Nanishi E, Nagata H, Yamamura K, Doi T, Ikeda K, Hara T
  • Journal Title: Pediatr Int Volume: 55(6) Pages: 801-2
• [Journal Article] Diagnostic imaging of a child with congenital internal jugular vein phlebectasia (2013)
  • Author(s): Nagata H, Uike K, Nakashima Y, Hirata Y, Yamamura K, Hara T
  • Journal Title: J Pediatr Volume: 163(4)
• [Journal Article] Left venricular efficiency after ligation of patent ductus arteriosus for premature infants (2013)
  • Author(s): Nagata H, Ihara K, Yamamura K, Tanoue Y, Shiokawa Y, Tominaga R, Hara T
  • Journal Title: J Thorac Cardiovasc Surg Volume: 146(6) Pages: 1353-8
• [Journal Article] Thrombocytosis in asplenia syndrome with congenital heart disease : A previously unrecognized risk factor for thromboembolism (2013)
  • Author(s): Yamamura K, Joo K, Ohga S, Nagata H, Ikeda K, Muneuchi J, Watanabe M, Hara T
  • Journal Title: Int J Cardiol Volume: 167(5) Pages: 2259-63
• [Journal Article] Balloon-occluded retrograde transvenous obliteration for congenital portosystemic venous shunt : report of two cases (2012)
  • Author(s): Nagata H, Yamamura K, Ikeda K, Ihara K, Hara T
  • Journal Title: Pediatr Int Volume: 54(3) Pages: 419-21
• [Journal Article] Efficacy of bosentan therapy for segmental pulmonary artery hypertension due to major aortopulmonary collateral arteries in children (2012)
  • Author(s): Yamamura K, Nagata H, Ikeda K, Ihara K, Hara T
  • Journal Title: Int J Cardiol Volume: 161(1)
• [Journal Article] Strok in a child safely treated with intravenous tissue plasminogen activator and edaravone, a free radical scavenger (2012)
  • Author(s): Baba H, Sugimori H, Nanishi E, Nagata H, Lee S, Kuwashiro T, Hashizume M
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 21(8)