Analysis of progression of atherosclerosis after Kawasaki disease by coronary arteritis mouse model

• Project/Area Number: 24791071
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Kyushu University
• Principal Investigator: TANAKA Tamami 九州大学, 大学病院, 研究員 (60423547)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 川崎病 / 自然免疫 / 動脈硬化

Research Abstract

Nod1 ligand induces Kawasaki disease-like coronary arteritis in mice. After coronary arteritis developed in ApoE KO mice by administration of Nod1 ligand, the progression of atherosclerosis was assessed. Atherosclerosis in coronary artritis-induced ApoE KO mice was progressed more than in not induced ApoE KO mice. And the progression was caused by production of cytokines and chemokines like Ccl5 and Cxcl16 in coronary artery. Furthermore, atherosclerosis in Nod1/ApoE double knockout mice progressed more slowly than that in ApoE KO mice. These finginds suggested that innate immune ligands possibly caused by Kawasaki disease would progress atherosclerosis.