Investigation into risk factors of pulmonary hypertension in Down syndrome
| Project/Area Number |
24791092
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Osaka Medical College |
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Principal Investigator |
Kishi Kanta 大阪医科大学, 医学部, 助教 (20408503)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ダウン症候群 / 肺高血圧 / 肺高血圧症 |
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| Outline of Final Research Achievements |
Down syndrome with congenital heart diseases has potential for early development of pulmonary hypertension. Dysregulation of bone marrow protein (BMP)2 signaling is responsible for pulmonary hypertension. In the current study, we examined the relationship between BMP2 signaling and Down syndrome related proteins including dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) and regulator of calcineurin (RCAN)1. In vitro study, BMP2 signaling affected expression of DYRK1A. This finding suggests the relationship between BMP2 signaling and DYRK1A. Further study will be needed to clarify this issue.
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Report
(5 results)
Research Products
(12 results)
