Investigation into risk factors of pulmonary hypertension in Down syndrome

• Project/Area Number: 24791092
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Osaka Medical College
• Principal Investigator: Kishi Kanta 大阪医科大学, 医学部, 助教 (20408503)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ダウン症候群 / 肺高血圧 / 肺高血圧症

Outline of Final Research Achievements

Down syndrome with congenital heart diseases has potential for early development of pulmonary hypertension. Dysregulation of bone marrow protein (BMP)2 signaling is responsible for pulmonary hypertension. In the current study, we examined the relationship between BMP2 signaling and Down syndrome related proteins including dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) and regulator of calcineurin (RCAN)1. In vitro study, BMP2 signaling affected expression of DYRK1A. This finding suggests the relationship between BMP2 signaling and DYRK1A. Further study will be needed to clarify this issue.

Research Products

• [Journal Article] Dehydroepiandrosterone Alters Retinol Status and Expression of the β-Carotene 15,15′-Monooxygenase and Lecithin:Retinol Acyltransferase Genes (2016)
  • Author(s): Takitani K, Miyazaki H, Koh M, Kishi K, Inoue A, Tamai H.
  • Journal Title: Journal of Nutritional Science and Vitaminology Volume: 62 Issue: 1 Pages: 12-18
  • DOI: 10.3177/jnsv.62.12
  • NAID: 130005148613
  • ISSN: 0301-4800, 1881-7742
  • Peer Reviewed / Open Access
• [Journal Article] Persistent high fever for more than 10 days during acute phase is a risk factor for endothelial dysfunction in children with a history of Kawasaki disease. (2015)
  • Author(s): Mori Y, Katayama H, Kishi K, Ozaki N, Shimizu T, Tamai H.
  • Journal Title: J Cardiol. Volume: pii: S0914-5087(15) Issue: 1 Pages: 00265-8
  • DOI: 10.1016/j.jjcc.2015.08.008
  • Peer Reviewed
• [Journal Article] Altered retinol status and expression of retinol-related proteins in streptozotocin-induced type 1 diabetic model rats (2015)
  • Author(s): Takitani K, Inoue K, Koh M, Miyazaki H, Kishi K, Inoue A, Tamai H.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 56 Issue: 3 Pages: 195-200
  • DOI: 10.3164/jcbn.14-113
  • NAID: 130005068186
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] α-Tocopherol Status and Altered Expression of α-Tocopherol-Related Proteins in Streptozotocin-Induced Type 1 Diabetes in Rat Models (2014)
  • Author(s): Takitani K, Inoue K, Koh M, Miyazaki H, Kishi K, Inoue A, Tamai H.
  • Journal Title: Journal of Nutritional Science and Vitaminology Volume: 60 Issue: 6 Pages: 380-386
  • DOI: 10.3177/jnsv.60.380
  • NAID: 130005060910
  • ISSN: 0301-4800, 1881-7742
  • Peer Reviewed / Open Access
• [Journal Article] Retinol Status and Expression of Retinol-Related Proteins in Methionine-Choline Deficient Rats (2014)
  • Author(s): Miyazaki H, Takitani K, Koh M, Inoue A, Kishi K, Tamai H.
  • Journal Title: Journal of Nutritional Science and Vitaminology Volume: 60 Issue: 2 Pages: 78-85
  • DOI: 10.3177/jnsv.60.78
  • NAID: 130004491369
  • ISSN: 0301-4800, 1881-7742
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 18トリソミー児において根治術により良好な肺循環が獲得され予後が改善される (2015)
  • Author(s): 岸 勘太、小田中豊、尾崎智康、片山博視、玉井 浩、根本慎太郎、内山敬達、吉村 健、峰 研治
  • Organizer: 第51回 日本小児循環器学会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-16
• [Presentation] Unguarded mitral orifice の一例 (2015)
  • Author(s): 岸 勘太
  • Organizer: 第29回 日本小児循環器学会 近畿・中四国地方会
  • Place of Presentation: 大阪
  • Year and Date: 2015-03-08
• [Presentation] 根治術を施行した18トリソミーにおける肺循環 (2015)
  • Author(s): 岸 勘太
  • Organizer: 第21回 日本小児肺循環研究会
  • Place of Presentation: 大阪
  • Year and Date: 2015-01-31
• [Presentation] 修復前のファロー四徴症ではNT pro-BNPは左心機能を反映する。 (2014)
  • Author(s): 岸 勘太
  • Organizer: 第50回日本小児循環器学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2014-07-03 – 2014-07-05
• [Presentation] 修復前のファロー四徴症ではNT pro-BNPは左心機能を反映する (2014)
  • Author(s): 岸 勘太 尾崎智康 片山博視 玉井 浩 根本 慎太郎 峰 研治 内山敬達 吉村 健
  • Organizer: 第50回日本小児循環器学会総会
  • Place of Presentation: 岡山
• [Presentation] Trisomy18に合併した心室中隔欠損症では肺動脈バンディングにより右心室機能が低下する (2013)
  • Author(s): 岸 勘太、尾崎智康、片山博視、玉井 浩、小澤英樹、根本慎太郎、内山敬達、吉村 健
  • Organizer: 第49回日本小児循環器学会総会
  • Place of Presentation: 東京
• [Presentation] 心手術を施行した先天性心疾患に合併した左室緻密化障害の臨床像 (2012)
  • Author(s): 岸 勘太、井上奈緒、尾崎智康、玉井 浩、根本 慎太郎、森 保彦、奥村謙一、内山敬達、吉村 健
  • Organizer: 第48回日本小児循環器学会総会
  • Place of Presentation: 京都