Evaluation between Cbr1 copy number resumpsion and several abnormalities in Ts1Cje; a model for Down syndrome

Research Project

Project/Area Number	24791097
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Pediatrics
Research Institution	Institute of Physical and Chemical Research
Principal Investigator	SHIMOHATA Atsushi 独立行政法人理化学研究所, 脳科学総合研究センター, リサーチアソシエイト (00624735)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	ダウン症候群 / 神経科学 / モデルマウス / 行動試験 / 脳科学 / 国際情報交換 / ダウン症 / 脳・神経
Research Abstract	The present study was designed to evaluate whether the copy number resumption of Cbr1 gene located on DS critical region might rescue phenotypes seen in Ts1Cje:a model mouse for DS. We prepared and analyzed the Ts1Cje/Cbr1(+/+/-) mice in which Cbr1 gene only is set back to a normal expression level. We found that Cbr1 gene was not directly involved in neither decreasing of Body weight, hyper activity and ventricular enlargement in Ts1Cje. However, its possible implication in learning and memory deficit or oxidative stress increase in Ts1Cje remains elusive. We should continue our assessment of gene copy number resumption and their potential rescue of Ts1Cje abnormalities.