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Establishment of prognostic factor(s) by analysis of genetic abnormality and elucidation of the mechanism of drug resistance in nephroblastoma

Research Project

Project/Area Number 24791099
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionResearch Institute for Clinical Oncology, Saitama Cancer Center

Principal Investigator

MASAYUKI Haruta  埼玉県立がんセンター(臨床腫瘍研究所), その他部局等, 研究員 (80392190)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords腎芽腫 / 予後因子 / WTX / 予後予測因子
Research Abstract

In nephroblastoma, identification of new prognostic markers for better therapy planning are needed to improve the mortality and recurrence rate, and prevent side and late effects. In this study, we examined genetic and epigenetic abnormalities of the 5 genes ( WT1, CTNNB1, WTX, TP53 and IGF2) and DNA methylation status of three tumor suppressor genes ( RASSF1A, DCR2 and CASP8) in Japanese nephroblastoma. WTX mutation and RASSF1A hypermethylation was correlated with poor prognosis by Kaplan-Meier analysis (p=0.040 and p=0.043, respectively). Nephroblastoma patients with both WTX and TP53 mutation particularly showed poor prognosis.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (22 results)

All 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results) Presentation (13 results) Remarks (3 results)

  • [Journal Article] RASSF1A methylation may have two biological roles in neuroblastoma tumorigenesis depending on the ploidy status and age of patients2014

    • Author(s)
      Haruta M, Kamijo T, Nakagawara A, Kaneko Y
    • Journal Title

      Cancer lett

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] RASSF1A methylation may have two biological roles in neuroblastoma tumorigenesis depending on the ploidy status and age of patients2014

    • Author(s)
      Haruta M, Kamijo T, Nakagawara A, Kaneko Y
    • Journal Title

      Cancer Lett

      Volume: 348 Issue: 1-2 Pages: 167-176

    • DOI

      10.1016/j.canlet.2014.03.022

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RASSF1A methylation indicates a poor prognosis in hepatoblastoma patients2013

    • Author(s)
      Honda S, Miyagi H, Suzuki H, Minato M, Haruta M, Kaneko Y, Hatanaka KC, Hiyama E, Kamijo T, Okada T, Taketomi A
    • Journal Title

      Pediatric Surgery International

      Volume: 29 Issue: 11 Pages: 1147-1152

    • DOI

      10.1007/s00383-013-3371-z

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Meiosis error and subsequent genetic alterations invoke the malignant transformation of germ cell tumor2013

    • Author(s)
      Kaneko Y, Ichikawa M, Arai Y, Haruta M, Furukawa S, Ariga T, Kajii T
    • Journal Title

      Genes Chromosomes Cancer

      Volume: 52 Issue: 3 Pages: 274-286

    • DOI

      10.1002/gcc.22027

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Different incidences of epigenetic but not genetic abnormalities between Wilms tumors in Japanese and Caucasian children2012

    • Author(s)
      Haruta M., et.al.
    • Journal Title

      Cancer Science

      Volume: (In press) Issue: 6 Pages: 1129-35

    • DOI

      10.1111/j.1349-7006.2012.02269.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Methylation of the RASSF1A promoter is predictive of poor outcome among patients with Wilms tumor2012

    • Author(s)
      Ohshima J, Haruta M, Fujiwara W, Watanabe N, Arai Y, Ariga T, Okita H, Koshinaga T, Oue T, Hinotsu S, Nakadate H, Horie H, Fukuzawa M, Kaneko Y
    • Journal Title

      Pediatr Blood Cancer

      Volume: 59 Issue: 3 Pages: 499-505

    • DOI

      10.1002/pbc.24093

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] WT1 mutation was identified in 83% and 100% of bilateral and familial Wilms tumors, respectively (JWiTS)2013

    • Author(s)
      Kaneko Y, et al.
    • Organizer
      第55回日本小児血液・がん学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] Methylation of the RASSF1A promoter is predictive of poor outcome among patients with Wilms tumor2013

    • Author(s)
      Ohshima J, et al.
    • Organizer
      第55回日本小児血液・がん学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 次世代シーケンサーを用いた肝芽腫のメチル化解析による予後予測マーカー確立の試み2013

    • Author(s)
      本田昌平、等
    • Organizer
      第55回日本小児血液・がん学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 日本ウィルムス腫瘍研究グループに登録された両側性腎芽腫の検討。2013

    • Author(s)
      大植孝治、等
    • Organizer
      第55回日本小児血液・がん学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 両側性Wilms腫瘍の83%、家族制Wilms腫瘍の全例にWT1遺伝子異常が同定された(日本Wilms腫瘍研究グループ)2013

    • Author(s)
      金子安比古、等
    • Organizer
      日本人類遺伝学会第58回大会.
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] Genetic and pathological analyses of bilateral or familial Wilms tumors incidate the inheritance mode of WT1 germline mutation and response to chemotherapy.2013

    • Author(s)
      Kaneko Y, et al.
    • Organizer
      45th Congress of the International Society of Paediatric Oncology
    • Place of Presentation
      Hong Kong
    • Related Report
      2013 Annual Research Report
  • [Presentation] Epigenetic analyses to establish a molecular-genetic marker for treatment outcome in hepatoblastoma2013

    • Author(s)
      Honda S, et al.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] WTX 遺伝子変異は腎芽腫の予後予測因子である2012

    • Author(s)
      春田雅之, 他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] WTX mutation is a new prognostic factor for Wilms tumor2012

    • Author(s)
      Haruta M, et. Al
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] WTX mutation is a new prognostic factor for Wilms tumor.2012

    • Author(s)
      Haruta M, et. al.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] Mechanism of Germ Cell Tumor Formation Identified by SNP Array Patterns and Methylation Status of Imprinted genes2012

    • Author(s)
      Ichikawa M, et. al.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] Genetic and epigenetic analyses to establish a molecular genetic marker for treatment outcome in hepatoblastomas2012

    • Author(s)
      Honda S, et. al.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] WTX遺伝子変異は腎芽腫の予後予測因子である2012

    • Author(s)
      春田雅之 他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Remarks] 埼玉県立がんセンター 臨床腫瘍研究所

    • URL

      http://www.saitama-cc.jp/rinsyousyuyoulabo/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 埼玉県立がんセンター 臨床腫瘍研究所

    • URL

      http://www.saitama-cc.jp/rinsyousyuyou-labo/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 埼玉県立がんセンター臨床腫瘍研究所

    • URL

      http://www.saitama-cc.jp/rinsyousyuyou_labo/index.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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