| Project/Area Number |
24791111
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | BDNF / コレステロール / 母子分離 / パルミトイル酸 / 母子分離モデル / パルミトレイン酸 / 神経細胞 / 発達 / シナプス |
|---|
| Research Abstract |
Brain-derived neurotrophic factor (BDNF) mediates neuronal cholesterol biosynthesis during synapse development. However the effect of early life stress on the BDNF-dependent lipid homeostasis in neurons is not well understood. Thus, we here investigated the crosstalk between stress and BDNF signaling. First, it was shown that cholesterol biosynthesis in neurons were not affected by the treatment with corticosterone while stress hormones were known to inhibit cholesterol biosynthetic pathway in non-neuronal cells. Second, we found that maternal deprivation reduced the expression of cholesterol biosynthetic enzymes. These results indicated a possibility that early life stress influenced BDNF-mediated cholesterol biosynthesis by decreasing their expression.
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