Project/Area Number |
24791114
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Embryonic/Neonatal medicine
|
Research Institution | Fukushima Medical University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 胎児プログラミング / 血流再分配 / 胎仔エコー |
Research Abstract |
I gave mice in early pregnancy stress such as the drug load and examined an embryonic heart hemodynamic change by performing embryonic ultrasound cardiography. Heart rate , fractional shortening, and cardiac output tended to increase by subcutaneous injecting 0.2 mg/kg of nicotine to a pregnant mice 15-30 minutes after the injection. On the other hand in embryos, carotid artery flow significantly decreased after nicotine injection in comparison with the control group that injected normal saline , and dorsal aorta and umbilical artery flows tended to decrease 15-30 minutes after the injection.This circulation adjustment is a reaction to lead to the blood flow redistribution, and is considered to influence the fetal programming such as an embryonic growth retardation or postnatal developmental disorders.
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