| Project/Area Number |
24791118
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 新生児仮死 / 低体温療法 / サイトカイン / 転写因子 / シグナル伝達分子 / 脳低温療法 |
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| Outline of Final Research Achievements |
We analyzed cytokine and transription factor levels in peripheral blood from 3 full-term infants with neonatal asphyxia who received body hypothermia therapy(severe group) and those from 15 full-term infants with neonatal asphyxia who did not received body hypothermia therapy(mild group) and those from 13 full-term infants without neonatal asphyxia(control group) on 0,1,2,3 day of life. We found that inflammatory cytokines were at higher level in the asphyxiated group. In mild group and control group, serum level of such inflammatory cytokines decreased over time, those are persist at high level in severe group. Serum level of IL10 decreased over time in three groups and serum level of Smad2 is significantly lower in severe group compared to the other groups.
Inflammation persists in neonates with severe asphyxia and body hypothermia therapy cannot help reduce inflammation of neonatal asphyxia.
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