The analisis of serum cytokine and transcription factor level on the pathophysiology of late-onset circulatory collapse of extremely low birth infant

Research Project

Project/Area Number	24791119
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Embryonic/Neonatal medicine
Research Institution	Jichi Medical University
Principal Investigator	MATANO MIYUKI 自治医科大学, 医学部, 助教 (90458315)
Project Period (FY)	2012-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000) Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords	晩期循環不全 / サイトカイン / 転写因子 / 心血管バイオマーカー
Outline of Final Research Achievements	We analyzed cytokine and transcription factor levels in peripheral blood from 6 extremely low birth weight(ELBW) infants with late-onset circulatory collapse and those from 11 ELBW without late-onset circulatory collapse. We found that inflammatory cytokines (IL-8,TNF-α) wear at hiher level in the late-onset circulatory collapse group.In these group, Serum level of IL-8 and TNF-α decreased over time.NT-proBNP was higher level in the both group.But we can not find significant differences between bith group.