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Effects of lipid nutrition and lipid metabolism on chronic lung disease in very low birth weight infants

Research Project

Project/Area Number 24791124
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionJuntendo University

Principal Investigator

SUGANUMA Hiroki  順天堂大学, 医学部, 助教 (60568004)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords早産児 / 慢性肺疾患 / 脂質 / DHA / 脂肪酸 / 極低出生体重児 / 栄養 / リポ蛋白
Research Abstract

We investigated the relation with chronic lung disease and lipid profiles in preterm infants. The relations with respiratory disorder and lipids profile at birth in preterm infants revealed that serum triglyceride levels and apoA-I levels significantly decreased in preterm infants with respiratory disorder. The fatty acid composition of the erythrocyte membrane was analysed at 14 and 28 days of age. The Arachidonic acid levels significantly increased, whereas alpha-linolenic acid significantly decreased, in very low birth weight infants with chronic lung disease at both time points. The results showed that lipids may influence the development of chronic lung disease and lung maturity in preterm infants.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (7 results)

  • [Journal Article] Fat emulsion given to very low-birthweight infants increases urinary L-FABP2014

    • Author(s)
      Suganuma H, Ikeda N, Ohkawa N, Nagata S, Shoji H, Shimizu T
    • Journal Title

      Pediatr Int

      Volume: 56(2) Issue: 2 Pages: 207-10

    • DOI

      10.1111/ped.12223

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 極低出生体重児における脂肪乳剤投与がリポ蛋白プロファイルに与える影響2013

    • Author(s)
      菅沼 広樹
    • Organizer
      第58回日本未熟児新生児学会学術集会
    • Place of Presentation
      石川
    • Related Report
      2013 Final Research Report
  • [Presentation] 人工呼吸管理を必要とした早産児における脂質代謝 サーファクタント投与の有無による検討2013

    • Author(s)
      毎熊敦子
    • Organizer
      第58回日本未熟児新生児学会学術集会
    • Place of Presentation
      石川
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of feeding type on lipoprotein profiles in very low birth weight infants at discharge2013

    • Author(s)
      Hiroki Suganuma
    • Organizer
      International Congress of Pediatrics
    • Place of Presentation
      オーストラリア
    • Related Report
      2013 Final Research Report
  • [Presentation] 栄養法の違いが極低出生体重児のリポ蛋白プロファイルに与える影響2013

    • Author(s)
      菅沼 広樹
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of feeding type on lipoprotein profiles in very low birth weight infants at discharge2013

    • Author(s)
      Hiroki Suganuma
    • Organizer
      International Congress of Pediatrics
    • Place of Presentation
      メルボルン
    • Related Report
      2013 Annual Research Report
  • [Presentation] 栄養法の違いが極低出生体重児のリポ蛋白プロファイルに与える影響2013

    • Author(s)
      菅沼広樹
    • Organizer
      日本小児科学会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report
  • [Presentation] 極低出生体重児における栄養法の違いに伴うLDLプロファイルの経時的変化2012

    • Author(s)
      菅沼広樹
    • Organizer
      日本未熟児新生児学会
    • Place of Presentation
      熊本
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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