| Project/Area Number |
24791126
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
YAMADA Souichi 国立感染症研究所, ウイルス第一部, 主任研究官 (10514119)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 胎盤 / サイトメガロウイルス / モルモット / 胎盤病態 / 遺伝子動態 / CMV / 先天性感染 / 経胎盤感染 / 胎盤組織培養 / マイクロアレイ |
|---|
| Research Abstract |
Human cytomegalovirus (HCMV) infection to pregnant women causes congenital infection to the fetus through the placenta. The virological analysis in placenta was performed using guinea pig and guinea pig CMV (GPCMV) model. In this study, the guinea pig placental tissue culture system and the system of quantitative measurement of changes in the gene in infected guinea pig placenta were established. By the quantitative analysis of the gene expression change in the infected placenta and cultured cell, the gene expression change was associated with the GPCMV infection. A gene expression change was recognized early in infection in the cultured cell.
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