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Immunological analysis of alopecia areata

Research Project

Project/Area Number 24791132
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionTohoku University

Principal Investigator

MIZUASHI Masato  東北大学, 大学病院, 助教 (20400369)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords円形脱毛症 / Th17
Research Abstract

T helper 17 cells, characterized by interleukin-17 (IL-17) production, play a critical role in the pathogenesis of autoimmune disease, including alopecia areata (AA). We employed immunohistochemical staining for IL-17-producing cells, as well as interferon-gamma-producing cells, granulysin-bearing cells and Foxp3+ regulatory T cells, and performed a quantitative analysis of IL-17-producing cells in the lesional skin of several clinical forms of AA by TissueFAXS analysis. Among them, interestingly, the ratio of IL-17-producing cells in acute, diffuse and total alopecia was significantly lower than those of multiple types of AA. Our study sheds light on one of the possible immunological mechanisms of AA.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Comparison of interleukin-17- producing cells in different clinical types of alopecia areata.2013

    • Author(s)
      Tojo G, Fujimura T, Kawano M, Ogasawara K, Kambayashi Y, Furudate S, Mizuashi M, Aiba S.
    • Journal Title

      Dermatology

      Volume: 227 Issue: 1 Pages: 78-82

    • DOI

      10.1159/000353159

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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