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The importance of mTOR pathway and autophagy mechanism in angiosarcoma survival

Research Project

Project/Area Number 24791133
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionTohoku University

Principal Investigator

NUMATA Yukikazu  東北大学, 大学病院, 助教 (30622980)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Toshiya  東北大学, 大学病院, 医員 (30712195)
Co-Investigator(Renkei-kenkyūsha) YAMASAKI Kenshi  東北大学, 大学院・医学系研究科, 准教授 (40294798)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords血管肉腫 / mTOR経路 / オートファジー
Research Abstract

The purpose of this study is to check the molecular condition of a patient mechanism of angiosarcoma which has poor prognosis. Especially, I expect mTOR course and participation of the automatic fuzzy mechanism in that with a main purpose. After, in 2012, examining the expression of related molecules with the angiosarcoma tissue for immunohistology; in comparison with a normalcy blood vessel wall strong; confirmed that developed, and what was activated constantly particularly an automatic fuzzy system course was suggested. After using a repressor and the automatic fuzzy repressor of the mTOR course in the culture system of the angiosarcoma cell, I confirmed the apoptotic instruction of the neoplastic cell. I confirmed the expression of both courses with the normal skin in 2013. As for these results, the inhibition of both courses suggested the possibility of new treatment of angiosarcoma.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (24 results)

All 2014 2013 2012 Other

All Journal Article (12 results) (of which Peer Reviewed: 10 results) Presentation (12 results)

  • [Journal Article] Generalized granulomatous dermatitis accompanied by myelodysplastic syndrome.2014

    • Author(s)
      Hagiwara A, Fujimura T, Furudate S, Kambayashi Y, Numata Y, Haga T, Aiba S.
    • Journal Title

      Acta Derm Venereol.

      Volume: 94 Issue: 2 Pages: 223-224

    • DOI

      10.2340/00015555-1656

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Squamous cell carcinoma arising from keratitis-ichthyosis-deafness syndrome2013

    • Author(s)
      Mayama H
    • Journal Title

      Acta Derm Venereol

      Volume: - Issue: 5 Pages: 583-584

    • DOI

      10.2340/00015555-1535

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple low-grade fibromyxoid sarcoma on the upper arms with atypical histological presentation.2013

    • Author(s)
      Furudate S, Fujimura T, Kambayashi Y, Tsukada A, Numata Y, Aiba S.
    • Journal Title

      Case Rep Dermatol.

      Volume: 5 Issue: 2 Pages: 152-155

    • DOI

      10.1159/000351791

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小児に生じた衛星病変を伴う青色母斑の1例2013

    • Author(s)
      古舘禎騎, 沼田透効, 塚田 全, 渡辺みか, 泉 美貴, 相場節也
    • Journal Title

      皮膚科の臨床

      Volume: 55 Pages: 585-588

    • URL

      http://ci.nii.ac.jp/naid/40019690831

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小児に生じた衛星病変を伴う青色母斑の1例2013

    • Author(s)
      古舘禎騎、沼田透効、塚田 全、渡辺みか、泉 美貴、相場節也
    • Journal Title

      皮膚科の臨床

      Volume: 55 Pages: 585-588

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD163+ adult xanthogranuloma arising from Merkel cell carcinoma treated with local radiotherapy2012

    • Author(s)
      Shimada, R., T. Fujimura, Y.Kambayashi, T. Ohtani, M. Nasu, Y. Numata, T. Haga, A. Hashimoto, and S. Aiba
    • Journal Title

      Acta Derm Venereol

      Volume: 92 Issue: 6 Pages: 631-632

    • DOI

      10.2340/00015555-1356

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of cutaneous botryomycosis with a combination of minocycline and topical heat therapy2012

    • Author(s)
      Ishibashi M, Numata Y, Tagami H, Aiba S
    • Journal Title

      Case Rep Dermatol

      Volume: 4 Issue: 2 Pages: 114-118

    • DOI

      10.1159/000338798

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phaeohyphomycosis Caused by Phaeoacremonium rubrigenum in an Immunosuppressive Patient : A Case Report and Review of the Literature2012

    • Author(s)
      Furudate S, Sasai S, Numata Y, Fujimura T, Aiba S
    • Journal Title

      Case Rep Dermatol

      Volume: 4 Issue: 2 Pages: 119-124

    • DOI

      10.1159/000339622

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Profiles of tumor- infiltrating lymphocytes in a case of trichilemmal carcinoma with spontaneous regression2012

    • Author(s)
      Furudate S, Fujimura T, Tsukada A, Numata Y, Kambayashi Y, Aiba S
    • Journal Title

      Case Rep Dermatol

      Volume: 4 Issue: 3 Pages: 215-221

    • DOI

      10.1159/000343881

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cutaneous squamous cell carcinoma developing from recessive dystrophic epidermolysis bullosa : a case report and an immunohistochemical study2012

    • Author(s)
      Tsukada A, Fujimura T, Furudate S, Kambayashi Y, Numata Y, Haga T, Hashimoto A, Aiba S
    • Journal Title

      Case Rep Dermatol

      Volume: 4 Issue: 3 Pages: 197-201

    • DOI

      10.1159/000343082

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 足底にみられたmelanoma in situ の早期病変2012

    • Author(s)
      沼田透効, 笹井 収
    • Journal Title

      皮膚病診療

      Volume: 43 Pages: 575-578

    • URL

      http://www.jamas.or.jp/user/database/Search/detail/scode/J01268

    • Related Report
      2013 Final Research Report
  • [Journal Article] 足底にみられたmelanoma in situの早期病変2012

    • Author(s)
      沼田 透効, 笹井 収
    • Journal Title

      皮膚病診療

      Volume: 34 Pages: 575-578

    • Related Report
      2012 Research-status Report
  • [Presentation] 加水分解コムギタンパク含有のシャンプーにより手から感作し発症したコムギアレルギーの1例2014

    • Author(s)
      塚田全、沼田透効、相場節也
    • Organizer
      第113回日本皮膚科学会総会
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 足底に生じた線状苔癬の1例2014

    • Author(s)
      吉田幸代、沼田透効、相場節也、熊坂中
    • Organizer
      宮城地方会第366回例会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多発性の脂漏性角化症に対するいぼ剥ぎ法の応用2013

    • Author(s)
      沼田透効, 東條玄一, 高橋隼也, 相場節也
    • Organizer
      第28回日本皮膚外科学会学術大会
    • Place of Presentation
      大津市
    • Related Report
      2013 Final Research Report
  • [Presentation] 蕁麻疹・血管浮腫における頚部側面X 線像を用いた気道浮腫の病型分類2013

    • Author(s)
      沼田透効, 相場節也
    • Organizer
      第112回日本皮膚科学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Final Research Report
  • [Presentation] 蕁麻疹・血管性浮腫における頚部側面X線像を用いた気道浮腫の病型分類2013

    • Author(s)
      沼田透効、相場節也
    • Organizer
      第112回日本皮膚科学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多発性の脂漏性角化症に対するいぼ剥ぎ法の応用2013

    • Author(s)
      沼田透効、東條玄一、高橋隼也、相場節也
    • Organizer
      第28回日本皮膚外科学会学術集会
    • Place of Presentation
      大津市
    • Related Report
      2013 Annual Research Report
  • [Presentation] サイトメガロウイルス(CMV)およびEpstein-Barr ウイルス(EBV) の再活性化を伴ったDrug-induced hypersensitivity syndrome(DIHS)の1 例2012

    • Author(s)
      古舘禎騎, 沼田透効, 塚田 全, 菊地克子, 相場節也, 黒木 茂
    • Organizer
      三県合同地方会第359回例会
    • Place of Presentation
      山形市
    • Year and Date
      2012-09-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 後出血を繰り返し, 後天性血友病13が疑われた鼻背の基底細胞上皮腫の1 例2012

    • Author(s)
      沼田透効, 那須めい, 相場節也, 惣宇利正善, 一瀬白帝
    • Organizer
      第76回日本皮膚科学会東部支部学術大会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Final Research Report
  • [Presentation] Horizontal Square Buried Suture(HSBS)の応用例2012

    • Author(s)
      沼田透効, 笹井 収, 松永 純, 相場節也
    • Organizer
      第27回日本皮膚外科学会総会
    • Place of Presentation
      盛岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] Horizontal Square Buried Suture (HSBS)の応用例2012

    • Author(s)
      沼田透効、笹井 収、松永 純、相場節也
    • Organizer
      第27回日本皮膚外科学会総会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 後出血を繰り返し、後天性血友病13が疑われた鼻背の基底細胞上皮腫の1例2012

    • Author(s)
      沼田透効、那須めい、相場節也、 惣宇利正善、一瀬白帝
    • Organizer
      第76回日本皮膚科学会東部支部学術大会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] サイトメガロウイルス (CMV)およびEpstein-Barrウイルス (EBV)の再活性化を伴ったDrug-induced hypersensitivity syndrome (DIHS)の1例

    • Author(s)
      古舘禎騎、沼田透効、塚田 全、菊地克子、 相場節也、黒木 茂
    • Organizer
      三県合同地方会第359回例会
    • Place of Presentation
      山形
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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