Role of mesenchymal stem cells in tumor angiogenesis
| Project/Area Number |
24791135
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Gunma University |
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Principal Investigator |
MOTEGI Sei-ichiro 群馬大学, 医学(系)研究科(研究院), 講師 (20420185)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 血管新生 / 間葉系幹細胞 / 悪性黒色腫 |
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| Research Abstract |
We previously demonstrated that pericytes are major sources of the secreted glycoprotein and integrin-ligand MFG-E8 in B16 melanoma tumors, and that MFG-E8 promotes angiogenesis mediated by integrin-growth factor receptor cross talk. In this study, we identified that MFG-E8 up-regulated mesenchymal stem cells (MSC)-induced angiogenesis and tumor growth of B16 melanoma in mice, suggesting that inhibition of MFG-E8 might use the therapy of melanoma.
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Report
(3 results)
Research Products
(4 results)
