Role of mesenchymal stem cells in tumor angiogenesis

Research Project

Project/Area Number	24791135
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Dermatology
Research Institution	Gunma University
Principal Investigator	MOTEGI Sei-ichiro 群馬大学, 医学(系)研究科(研究院), 講師 (20420185)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	血管新生 / 間葉系幹細胞 / 悪性黒色腫
Research Abstract	We previously demonstrated that pericytes are major sources of the secreted glycoprotein and integrin-ligand MFG-E8 in B16 melanoma tumors, and that MFG-E8 promotes angiogenesis mediated by integrin-growth factor receptor cross talk. In this study, we identified that MFG-E8 up-regulated mesenchymal stem cells (MSC)-induced angiogenesis and tumor growth of B16 melanoma in mice, suggesting that inhibition of MFG-E8 might use the therapy of melanoma.

Report

(3 results)