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Studies on expression regulation of lysophospholid synthesis enzymes by steroids

Research Project

Project/Area Number 24791138
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionThe University of Tokyo

Principal Investigator

SUMIDA Hayakazu  東京大学, 医学部附属病院, 助教 (30609706)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords脂質 / リゾリン脂質合成酵素 / ステロイド / 癌 / 脂肪 / グルココルチコイド受容体
Research Abstract

Autotaxin (ATX) is the enzyme responsible for the production of lysophosphatidic acid with diverse functions. This study revealed that mRNA expression level of ATX was decreased by steroid treatment in ATX-expressing cells. Furthermore, decreased serum ATX antigen levels were observed after the initiation of treatment with steroids for patients. The decreased levels recovered during tapering of PSL dose in a dose-dependent manner. In addition, considering the results of experiments using murine epididymal adipose tissue, decrease of serum ATX levels by steroids might be due to the decrease of ATX production from adipose tissue.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Decrease in circulating autotaxin by oral administration of prednisolone2013

    • Author(s)
      Sumida H
    • Journal Title

      Clin Chim Acta

      Volume: 415 Pages: 74-80

    • DOI

      10.1016/j.cca.2012.10.003

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decrease in circulating autotaxin by oral administration of prednisolone2012

    • Author(s)
      Sumida H, Nakamura K, Yanagida K, Ohkawa R, Asano Y, Kadono T, Tamaki K, Igarashi K, Aoki J, Sato S, Ishii S, Shimizu T, Yatomi Y
    • Journal Title

      Clin Chim Acta

      Volume: 415C Pages: 74-80

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Patent(Industrial Property Rights)] オートタキシン測定によるステロイド服用効果の検査方法2012

    • Inventor(s)
      石井聡, 住田 隼一, 矢冨 裕, 中村和宏, 佐藤 伸一, 門野 岳史, 五十嵐 浩二
    • Industrial Property Rights Holder
      国立大学法人東京大学, 東ソー株式会社
    • Industrial Property Rights Type
      特許
    • Patent Publication Number
      2012-002588
    • Acquisition Date
      2012-01-05
    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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