Anti-IL-6 antibody attenuates TNF-alpha and cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer

• Project/Area Number: 24791142
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Kanazawa University
• Principal Investigator: SAITO Yuki 金沢大学, 大学病院, 助教 (90547168)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 虚血再潅流傷害 / 褥瘡 / TNF-α / IL-6 / iNOS / 接着分子

Research Abstract

In a mouse model of cutaneous ischemia-reperfusion injury, local administration of anti-IL-6 antibody inhibited expression of TNF-alpha and inducible nitric oxide synthase, and reduced cytotoxicity of them. And we checked the safeness about intradermal injection with anti-IL-6 antibody.From that reason, I suggest that anti-IL-6 antibody treatment might prevent the pressure ulcers.