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Blocking effect for percutaneous HIV infection by exposure of semen collected after oral administration of Maraviroc

Research Project

Project/Area Number 24791143
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionUniversity of Yamanashi

Principal Investigator

MATSUZAWA Takamitsu  山梨大学, 医学部附属病院, 医員 (40568028)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsHIV感染予防法 / 国内研究
Research Abstract

In light of the absence of a prophylactic vaccine, therapeutic strategies that reduce sexual transmission of HIV are urgently needed.
In this study, we evaluated whether exposure of semen collected after oral administration of Maraviroc (MVC), which is a orally available antagonist for CCR5 and has been clinically used for AIDS therapy, demonstrated potent blocking effect for HIV infection or not. We evaluated by using an ex vivo skin explant model. Even if volunteers were orally administrated MVC (600mg/day) for 1, 2, 3, or 14 days and then semen was collected, exposure of semen to epidermal sheets obtained from another volunteers had not significant blocking effect for HIV infection in epidermal LCs.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Oral administration of the CCR5 inhibitor , maraviroc, blocks HIV ex vivo infection of Langerhans cells within the epithelium2013

    • Author(s)
      Matsuzawa T, Kawamura T, Ogawa Y, Takahashi M, Aoki R, Moriishi K, Koyanagi Y, Gatanaga H, Blauvelt A, Shimada S
    • Journal Title

      J Invest Dermatol

      Volume: 133(12) Issue: 12 Pages: 2803-5

    • DOI

      10.1038/jid.2013.215

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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