| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In the plasma of patients of chronic urticaria, the amount of thrombin produced by adding tissue factor (TF) or phosphatidyl serine was increased. It suggested the fact that the enhancement of extrinsic coagulation was associated with the pathophysiology of chronic urticaria. Also, TF was expressed when human umbilical vein endothelial cells were stimulated by histamine or lipopolysaccharide. The TF expression induced by histamine was suppressed by adding histamine H1 receptor antagonist.
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