| Project/Area Number |
24791161
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kochi University |
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Principal Investigator |
SHIGA Takeo 高知大学, 教育研究部医療学系, 助教 (70444768)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 乾癬 / T細胞 / Th17 / Il-17 / TNF阻害薬 / TNF受容体 / IL-17 |
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| Research Abstract |
Recent reports showed slight increase of Th17 in psoriasis patients.We studied about the difference of Th17 induction between psoriasis patients and healthy donors using peripheral blood mononuclear cells(PBMC).As a result, mRNA expression of IL-17A and IFN-gamma were increased in both of the groups, however in psoriasis patients, mRNA expression levels of IFN-gammma were lower than healthy donors.These results indicated that under Th17 polarized condition, the balance of each cytokine was different between psoriasis patients and healthy donors.
Next, we focused on T cells because marked infiltration of lymphocytes in the lesion is one of the important histological findings of psoriasis. Under Th17 polarized condition, T cells obtained from psoriasis patients and healthy donors produced not only IL-17A but also TNF-alpha and TNF inhibitors suppressed IL-17A production.These results suggested that TNF inhibitors directly target Th17 in the pathogenesis of psoriasis.
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