Analysis of the therapeutic role of the inflammatory skin disease by IL-27
| Project/Area Number |
24791183
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
IMAI Yasutomo 兵庫医科大学, 医学部, 非常勤講師 (10529514)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | IL-27 / サイトカイン |
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| Research Abstract |
The inhibitory effect or therapeutic role of IL-27 in the differentiation of Tc17 cells is unknown. IL-27 is a heterodimeric cytokine composed of p28 and Epstein-Barr virus induced gene 3. Previous studies showed that IL-27 has an inhibitory action for the development of Th2 cells and Th17 cells. Contact hypersensitivity (CHS) is a mouse model of allergic contact dermatitis. We found that increased IL-17 and IL-22 production from CD8+ T cells in hapten-induced CHS mice regional lymph nodes. We also found that IL-27 inhibited IL-17 and IL-22 production from Tc17 cells. In addition, IL-27 transgenic mice showed diminished ear swelling in vivo.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Knocking-in the R142C mutation in transglutaminase 1 disrupts the stratum corneum barrier and postnatal survival of mice.2012
Author(s)
Nakagawa N, Yamamoto M, Imai Y, Sakaguchi Y, Takizawa T, Ohta N, Yagi N, Hatta I, Hitomi K, Takizawa T, Takeda J, Tsuda T, Matsuki M, Yamanishi K
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Journal Title
J Dermatol Sci
Volume: 65
Pages: 196-206
Related Report
Peer Reviewed
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[Presentation] 多彩な臨床症状を示した乾癬性関節炎にインフリキシマブの点滴時間短縮でアナフィラキーショックを起こしアダリムマブに変更し軽快した1症例2013
Author(s)
松井 聖, 今井康友, 横山雄一, 阿部武生, 荻田千絵, 吉川卓宏, 古川哲也, 石津 桃, 高田美樹, 田中克典 , 斎藤篤史 , 西岡亜紀, 関口昌弘, 東 直人, 北野将康, 角田慎一郎, 山西清文, 佐野 統
Organizer
日本脊椎関節炎学会第23回学術集会
Place of Presentation
東京
Year and Date
2013-09-14
Related Report
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