Analysis of the therapeutic role of the inflammatory skin disease by IL-27

• Project/Area Number: 24791183
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Hyogo Medical University
• Principal Investigator: IMAI Yasutomo 兵庫医科大学, 医学部, 非常勤講師 (10529514)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: IL-27 / サイトカイン

Research Abstract

The inhibitory effect or therapeutic role of IL-27 in the differentiation of Tc17 cells is unknown. IL-27 is a heterodimeric cytokine composed of p28 and Epstein-Barr virus induced gene 3. Previous studies showed that IL-27 has an inhibitory action for the development of Th2 cells and Th17 cells. Contact hypersensitivity (CHS) is a mouse model of allergic contact dermatitis. We found that increased IL-17 and IL-22 production from CD8+ T cells in hapten-induced CHS mice regional lymph nodes. We also found that IL-27 inhibited IL-17 and IL-22 production from Tc17 cells. In addition, IL-27 transgenic mice showed diminished ear swelling in vivo.

Research Products

• [Journal Article] Immediate-type contact hypersensitivity is reduced in interleukin-33 knockout mice (2014)
  • Author(s): Imai Y, Yasuda K, Sakaguchi Y, Futatsugi-Yumikura S, Yoshimoto T, Nakanishi K, Yamanishi K
  • Journal Title: J Dermatol Sci Volume: 74 Pages: 159-161
  • Peer Reviewed
• [Journal Article] Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice (2013)
  • Author(s): Imai Y, Yasuda K, Sakaguchi Y, Futatsugi-Yumikura S, Yoshimoto T, Nakanishi K, Yamanishi K
  • Journal Title: Proc Natl Acad Sci of USA. Volume: 110(34) Issue: 34 Pages: 13921-13926
  • DOI: 10.1073/pnas.1307321110
  • Peer Reviewed
• [Journal Article] Serum cytokines correlated with the disease severity of generalized pustular psoriasis (2013)
  • Author(s): Yamamoto M, Imai Y, Sakaguchi Y, Haneda T, Yamanishi K
  • Journal Title: Dis Markers Volume: 34 Pages: 153-161
  • Peer Reviewed
• [Journal Article] YKL-40 is a serum biomarker reflecting the severity of cutaneous lesions in psoriatic arthritis (2013)
  • Author(s): Imai Y, Aochi S, Iwatsuki K, Sano H, Yamanishi K
  • Journal Title: J Dermatol Volume: 40 Pages: 294-6
  • Peer Reviewed
• [Journal Article] Reseveratrol reverses remodeling in hearts with large, old myocardial infarctions through enhanced autophagy-activating AMP kinase pathway (2012)
  • Author(s): Kanamori H
  • Journal Title: Am J Pathol Volume: 182 Issue: 4 Pages: 701-7013
  • DOI: 10.1016/j.jaad.2012.09.037
  • Peer Reviewed
• [Journal Article] Knocking-in the R142C mutation in transglutaminase 1 disrupts the stratum corneum barrier and postnatal survival of mice. (2012)
  • Author(s): Nakagawa N, Yamamoto M, Imai Y, Sakaguchi Y, Takizawa T, Ohta N, Yagi N, Hatta I, Hitomi K, Takizawa T, Takeda J, Tsuda T, Matsuki M, Yamanishi K
  • Journal Title: J Dermatol Sci Volume: 65 Pages: 196-206
  • Peer Reviewed
• [Journal Article] Interleukin-17- and protease-activated receptor 2-mediated production of CXCL1 and CXCL8 modulated by cyclosporine A, vitamin D(3) and glucocorticoids in human keratinocytes (2012)
  • Author(s): Takei-Taniguchi R, Imai Y, Ishikawa C, Sakaguchi Y, Nakagawa N, Tsuda T, Hollenberg MD, Yamanishi K
  • Journal Title: J Dermatol Volume: 39 Pages: 625-31
  • Peer Reviewed
• [Presentation] Skin-specific expression of IL-33 causes atopic dermatitis-like inflammation with activation of group 2 innate lymphoid cells in mice (2014)
  • Author(s): Imai Y, Yasuda K, Sakaguchi Y, Mizutani H, Yoshimoto T, Nakanishi K, Yamanishi K
  • Organizer: 15th International conference on lymphocyte activation and immune regulation [the International Conference on Innate-Like cells in Irvine]
  • Place of Presentation: California, USA
• [Presentation] Skin-specific expression of IL-33 causes atopic dermatitis-like inflammation with activation of group 2 innate lymphoid cells in mice (2014)
  • Author(s): Imai Y, Yasuda K, Sakaguchi Y, Mizutani H, Yoshimoto T, Nakanishi K, Yamanishi K
  • Organizer: 15th International conference on lymphocyte activation and immune regulation
  • Place of Presentation: California, USA
  • Invited
• [Presentation] 多彩な臨床症状を示した乾癬性関節炎にインフリキシマブの点滴時間短縮でアナフィラキーショックを起こしアダリムマブに変更し軽快した1症例 (2013)
  • Author(s): 松井 聖, 今井康友, 横山雄一, 阿部武生, 荻田千絵, 吉川卓宏, 古川哲也, 石津 桃, 高田美樹, 田中克典 , 斎藤篤史 , 西岡亜紀, 関口昌弘, 東 直人, 北野将康, 角田慎一郎, 山西清文, 佐野 統
  • Organizer: 日本脊椎関節炎学会第23回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-09-14
• [Presentation] 乾癬34例に対する生物学的製剤の治療効果の検討 (2013)
  • Author(s): 古川紗綾佳, 今井康友, 山本雅章, 夏秋優, 山西清文
  • Organizer: 第28回日本乾癬学会学術大会
  • Place of Presentation: 東京
• [Presentation] IL-33 KO mice exhibit the reduced immediate type contact hypersensitivity (2013)
  • Author(s): Imai Y, Haneda T, Yasuda K, Yoshimoto T, Nakanishi K, Yamanishi K
  • Organizer: International Investigative Dermatology 2013
  • Place of Presentation: Edinburgh, UK
• [Presentation] 乾癬３４例に対する生物学的製剤の治療効果の検討 (2013)
  • Author(s): 古川紗綾佳, 今井康友, 山本雅章, 夏秋優, 山西清文
  • Organizer: 第28回日本乾癬学会学術大会
  • Place of Presentation: 東京
• [Presentation] IL-33 KO mice exhibit the reduced immediate type contact hypersensitivity (2013)
  • Author(s): Imai Y, Haneda T, Yasuda K, Yoshimoto T, Nakanishi K, Yamanishi K
  • Organizer: International Investigative Dermatology 2013
  • Place of Presentation: Edinburgh, Scotland, UK
• [Presentation] IL-27 はTc17 誘導を抑制して接触過敏症を減弱させる (2012)
  • Author(s): 今井康友, 善本隆之, 中西憲司, 山西清文, 善本知広
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪
• [Presentation] IL-27 ameliorates contact hypersensitivity via suppression of Tc17 differentiation in mice (2012)
  • Author(s): Imai Y, Yoshimoto T, Yoshimoto T, Nakanishi K, Yamanishi K
  • Organizer: 10th Meeting of the German-Japanese Society of Dermatology
  • Place of Presentation: Tokushima, Japan
• [Presentation] Serum YKL-40 as a possible biomarker for psoriatic arthritis (2012)
  • Author(s): Yamanishi K, Imai Y, Seiko A, Iwatsuki K, Sano H
  • Organizer: The 42nd annual ESDR Meeting
  • Place of Presentation: Venice, Italy
• [Presentation] 関節性乾癬の病勢と血中YKL-40 (Chitinase 3-Like-1)値の検討 (2012)
  • Author(s): 真鍋 蘭, 今井康友, 山西清文, 佐野 統, 青地聖子, 岩月啓氏(岡山大)
  • Organizer: 第27回日本乾癬学会学術大会
  • Place of Presentation: 新潟
• [Presentation] ウステキヌマブを投与した乾癬の6例 (2012)
  • Author(s): 石村直也, 今井康友, 真鍋 蘭, 羽田孝司, 山西清文
  • Organizer: 第111回日本皮膚科学会総会
  • Place of Presentation: 京都
• [Presentation] IL-27はTc17誘導を抑制して接触過敏症を減弱させる (2012)
  • Author(s): 今井康友, 善本隆之, 中西憲司, 山西清文, 善本知広
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪
• [Presentation] IL-27 ameliorates contact hypersensitivity via suppression of Tc17 differentiation in mice (2012)
  • Author(s): Imai Y, Yoshimoto T, Yoshimoto T, Nakanishi K, Yamanishi K
  • Organizer: 10th Meeting of the German-Japanese Society of Dermatology
  • Place of Presentation: 徳島