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Elucidation of pathophysiology of stress vulnerability by cerebrovascular deficits

Research Project

Project/Area Number 24791193
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionTohoku University

Principal Investigator

YOSHIZAKI Kaichi  東北大学, 医学(系)研究科(研究院), 助教 (50393161)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords血管性うつ病 / ストレス脆弱性 / 臨界期 / 大脳半球優位性 / 脳血管障害
Research Abstract

In the present study, we tried to identify critical period for stress vulnerability by cerebrovascular deficits. Mice were subjected to sham or left unilateral common carotid artery occlusion (UCCAO), and were, immediately or after two weeks, exposed to glucocorticoid, a kind of stress hormone, for two weeks. Then the mice were performed behavioral analyses related to depression. In the result, mice with both sham and left UCCAO exhibited depressive-like behavior in sucrose preference test when exposed glucocorticoid for four weeks. Intriguingly mice with left UCCAO exhibited depressive-like behavior when exposed glucocorticoid for last two weeks. These results suggest that there might be critical period for stress vulnerability during chronic phase after cerebrovascular deficits.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (25 results)

All 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (23 results)

  • [Journal Article] A sensitive period for GABAerngic interneuron in the dentate gyrus in modulating sensorimotor gating.2013

    • Author(s)
      Guo N., Yoshizaki K., Kimura R., Suto F. Yanagawa Y., Osumi N.
    • Journal Title

      J Neurosci.

      Volume: 33 Issue: 15 Pages: 6691-9704

    • DOI

      10.1523/jneurosci.0032-12.2013

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural crest-derived cells as tissue stem cells in the adult olfactory epithelium2013

    • Author(s)
      Suzuki J., Yoshizaki K., Kobayashi T., Osumi N
    • Journal Title

      Neurosci Res

      Volume: 75(2) Issue: 2 Pages: 112-20

    • DOI

      10.1016/j.neures.2012.11.005

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 父親の高齢化がマウスの自閉症様行動異常に及ぼす影響の解析2014

    • Author(s)
      木村龍一, 吉崎嘉一, 稲田仁, 大隅典子
    • Organizer
      第3回東北脳科学ウィンタースクール
    • Place of Presentation
      大崎
    • Year and Date
      2014-02-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Pax6 deficiency accelerates onset of an autistic behavior by advanced paternal age in the mouse2013

    • Author(s)
      Yoshizaki K., Kimura R., Inada H., Osumi N
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-05
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Paternal aging decreases pups' mother call in the mouse with acceleration by Pax6 haploinsufficiency : insight on genetic and epigenetic influence2013

    • Author(s)
      Yoshizaki K., Kimura R., Inada H., Osumi N
    • Organizer
      Society for Neuroscience, Cell symposium, Networked Brain
    • Place of Presentation
      San Diego
    • Year and Date
      2013-11-07
    • Related Report
      2013 Final Research Report
  • [Presentation] A study for the influence of virtual exercise on adult hippocampal neurogenesis2013

    • Author(s)
      Yoshizaki K., Osumi N
    • Organizer
      Neurogenesis International Symposium
    • Place of Presentation
      Matsushima
    • Year and Date
      2013-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 脂肪酸結合タンパク質の蝸牛における機能解析-聴覚アンチエイジングモデルマウスの発見-2013

    • Author(s)
      鈴木淳, 大島猛史, 吉田尚弘, 木村龍一, 吉崎嘉一, 高田雄介, 大和田祐二, 小林俊光, 大隅典子
    • Organizer
      第5回聴覚アンチエイジング研究会
    • Place of Presentation
      東京
    • Year and Date
      2013-07-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 脂肪酸結合タンパク質(Fabp)の蝸牛における機能解析-加齢性難聴になりにくいマウスの発見-2013

    • Author(s)
      鈴木淳, 大島猛史, 吉田尚弘, 木村龍一, 吉崎嘉一, 高田雄介, 大和田祐二, 小林俊光, 大隅典子
    • Organizer
      第13回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Influence of chronic subcortical ischemia on anhedonia-like behavior in mice2013

    • Author(s)
      Yoshizaki K., Wakita H., Osumi N
    • Organizer
      第11回WFSBP
    • Place of Presentation
      京都
    • Year and Date
      2013-06-24
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Pax6 modulates predisposition of autism by advanced paternal age in mouse2013

    • Author(s)
      Yoshizaki K., Kimura R., Osumi N
    • Organizer
      第36回日本神経科学会
    • Place of Presentation
      京都
    • Year and Date
      2013-06-22
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] The effect of Pax6 haploinsufficiency on mouse ultrasonic vocalization2013

    • Author(s)
      Kimura R., Yoshizaki K., Sugiyama T., Suzuki J., Nakamura R., Osumi N
    • Organizer
      第36回日本神経科学会
    • Place of Presentation
      京都
    • Year and Date
      2013-06-22
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Paternal aging decreases pups’ mother call in the mouse with acceleration by Pax6 haploinsufficiency: insight on genetic and epigenetic influence2013

    • Author(s)
      Yoshizaki K., Kimura R., Inada H., Osumi N.
    • Organizer
      Society for Neuroscience, Cell symposium, Networked Brain
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] A study for the influence of virtual exercise on adult hippocampal neurogenesis2013

    • Author(s)
      Yoshizaki K., Osumi N.
    • Organizer
      Neurogenesis International Symposium,
    • Place of Presentation
      松島
    • Related Report
      2013 Annual Research Report
  • [Presentation] Subcortical ischemia in the left hemisphere exacerbates depressive phenotypes ; a mouse model for vascular depression2012

    • Author(s)
      Yoshizaki K., Kimura R., Wakita H., Osumi N
    • Organizer
      第55回日本神経化学大会
    • Place of Presentation
      神戸
    • Year and Date
      2012-10-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Behavioral analysis of Pax6 heterozygous mutant mice2012

    • Author(s)
      木村龍一, 吉崎嘉一, 鈴木淳, 中村龍司, 大隅典子
    • Organizer
      第34回生物学的精神医学会
    • Place of Presentation
      神戸
    • Year and Date
      2012-09-28
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Influence of simulated experience of exercise on adult hippocampal neurogenesis2012

    • Author(s)
      Yoshizaki K., Osumi N
    • Organizer
      第35回日本神経科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of ultrasonic vocalization in Pax6 heterozygous mutant mice2012

    • Author(s)
      Kimura R., Yoshizaki K., Suzuki J., Nakamura R., Osumi N
    • Organizer
      第35回日本神経科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Pax6 affects distribution of interneuron in prefrontal cortex of mice2012

    • Author(s)
      Nakamura R., Haba H., Katsuyama Y., Yoshizaki K., Osumi N
    • Organizer
      第35回日本神経科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Subcortical ischemia in the left hemisphere involved in actualization of stress-induced anhedonia-like behavior2012

    • Author(s)
      Yoshizaki K., Kimura R., Wakita H., Osumi N
    • Organizer
      包括脳ネットワーク夏のワークショップ
    • Place of Presentation
      仙台
    • Year and Date
      2012-07-26
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Behavioral analysis of Pax6 heterozygous mutant mice2012

    • Author(s)
      木村龍一, 吉崎嘉一, 鈴木淳, 中村龍司, 大隅典子
    • Organizer
      包括脳ネットワーク夏のワークショップ
    • Place of Presentation
      仙台
    • Year and Date
      2012-07-26
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 胎生期由来介在ニューロンの発生に対する転写制御因子Pax6の関与について2012

    • Author(s)
      中村龍司, 勝山裕, 吉崎嘉一, 羽場芙弥, 大隅典子
    • Organizer
      包括脳ネットワーク夏のワークショップ
    • Place of Presentation
      仙台
    • Year and Date
      2012-07-26
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Subcortical ischemia in the left hemisphere exacerbates depressive phenotypes; a mouse model for vascular depression2012

    • Author(s)
      Yoshizaki K., Kimura R., Wakita H., Osumi N.
    • Organizer
      第55回日本神経化学大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Influence of stimulated experience of exercise on adult hippocampal neurogenesis2012

    • Author(s)
      Yoshizaki K., Osumi N.
    • Organizer
      第35回日本神経科学学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Analysis of ultrasonic vocalization in Pax6 heterozygous mutant mice2012

    • Author(s)
      Kimura R., Yoshizaki K., Suzuki J., Nakamura R., Osumi N.
    • Organizer
      第35回日本神経科学学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Pax6 affects distribution of interneuron in prefrontal cortex of mice2012

    • Author(s)
      Nakamura R., Haba H., Katsuyama Y., Yoshizaki K., Osumi N.
    • Organizer
      第35回日本神経科学学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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