Effects of oxytocin administration on anorexia nervosa -a near-infrared spectroscopy (NIRS) study-

• Project/Area Number: 24791195
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Gunma University
• Principal Investigator: TAKEI Yuichi 群馬大学, 医学部附属病院, 助教 (30455985)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: NIRS / 光トポグラフィー

Outline of Final Research Achievements

We hypothetised that the some of patients with Anorexia nervosa (AN) have combined autistic spectrum disorder, and investigated the brain function using near infrared spectroscopy (NIRS) during the face-to-face conversation task that reflect social function and the verbal fluency task that have been investigated in various psychiatric disorders.
The brain activation of AN patients during the conversation task was almost maintained compared to healthy subjects. On the other hand, we found that the brain activation in some cases of AN during the verbal fluency task indicated the bipolar disorder like pattern (delayed activation peak). Also, we found the depression like brain activation pattern (lowered brain activation) in one AN at the weight loss, and the lowered brain activation was increased with recovered body weight.

Research Products

• [Journal Article] Relationship of γ-aminobutyric acid and glutamate+glutamine concentrations in the perigenual anterior cingulate cortex with performance of Cambridge Gambling Task. (2015)
  • Author(s): Fujihara K, Narita K, Suzuki Y, Takei Y, Suda M, Tagawa M, Ujita K, Sakai Y, Narumoto J, Near J, Fukuda M.
  • Journal Title: Neuroimage Volume: 109 Pages: 102-8
  • DOI: 10.1016/j.neuroimage.2015.01.014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Near-infrared spectroscopic study of frontopolar activation during face-to-face conversation in major depressive disorder and bipolar disorder (2014)
  • Author(s): Takei Y, Suda M, Aoyama Y, Sakurai N, Tagawa M, Motegi T, Yamaguchi M, Narita K, Fukuda
  • Journal Title: J Psychiatr Res Volume: 57 Pages: 74-83
  • DOI: 10.1016/j.jpsychires.2014.06.009
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Temporal lobe and inferior frontal gyrus dysfunction in patients with schizophrenia during face-to-face conversation: a near-infrared spectroscopy study (2013)
  • Author(s): Takei Y, Suda M, Aoyama Y, Yamaguchi M, Sakurai N, Narita K, Fukuda M, Mikuni M
  • Journal Title: J Psychiat Res Volume: 47 Issue: 11 Pages: 1581-9
  • DOI: 10.1016/j.jpsychires.2013.07.029
  • Peer Reviewed
• [Journal Article] Reduced Dorsolateral Prefrontal Cortex Hemodynamic Response in Adult Obsessive-Compulsive Disorder as Measured by Near-Infrared Spectroscopy during the verbal fluency task. (2013)
  • Author(s): Hirosawa R, Narumoto J, Sakai Y, Nishida S, Ishida T, Nakamae T, Takei Y, Fukui K.
  • Journal Title: Neuropsychiatr Dis Treat. Volume: 9 Pages: 955-962
  • DOI: 10.2147/ndt.s45402
  • Peer Reviewed
• [Journal Article] Associations among parenting experiences during childhood and adolescence, hypothalamus-pituitary-adrenal axis hypoactivity, and hippocampal gray matter volume reduction in young adults (2012)
  • Author(s): Narita K, Fujihara K, Takei Y, Suda M, Aoyama Y, Uehara T, Majima T, Kosaka H, Amanuma M, Fukuda M, Mikuni M
  • Journal Title: Hum Brain Mapp Volume: 33 Issue: 9 Pages: 2211-2223
  • DOI: 10.1002/hbm.21354
  • Peer Reviewed
• [Journal Article] Micropolygyria in an infant born to a patient with severe anorexia nervosa: a case report. (2012)
  • Author(s): Takei Y, Suda M, Aoyama Y, Narita K, Kameyama M, Uehara T, Fukuda M, Mikuni M
  • Journal Title: Int J Eat Disord Volume: 45 Pages: 447-9
  • Peer Reviewed
• [Journal Article] Changes in Gray Matter Volume with Rapid Body Weight Changes in-Anorexia Nervosa : A Voxel-Based Morphometric Study (2011)
  • Author(s): Suda M, Narita K, Takei Y, Aoyama Y, et al
  • Journal Title: Biological Psychiatry Volume: 70 Issue: 8 Pages: 35-6
  • DOI: 10.1016/j.biopsych.2011.03.034
  • Peer Reviewed
• [Presentation] ワーキングメモリー課題中の神経オシレーションと神経伝達物質の関係： MRS とMEG によるマルチモダリティー研究 (2014)
  • Author(s): 茂木智和 , 武井雄一 , 藤原和之 , 鈴木雄介 , 田川みなみ , 笠木真人 , 山口美穂 , 成田耕介 , 福田正人
  • Organizer: 第44回日本臨床神経生理学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-20
• [Presentation] ヒト安静時MEG の前部帯状回におけるγ帯域活動とMRS によるGABA 濃度の関連について (2014)
  • Author(s): 田川みなみ、藤原和之、笠木真人 、茂木智和 、鈴木雄介、高橋啓介、青山義之、武井雄一、成田耕介、福田正人
  • Organizer: 第44回日本臨床神経生理学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-20
• [Presentation] 脳磁図による解析技術の発展と精神疾患研究の展開 (2014)
  • Author(s): 武井雄一
  • Organizer: 日本臨床脳磁図コンソーシアム (日本臨床神経生理学会 サテライトシンポジウム)
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-18
  • Invited
• [Presentation] The relationship between neurotransmitters and neural oscillation during working memory task: a combined magnetic resonance spectroscopy and magnetoencephalography study (2014)
  • Author(s): Yuichi Takei, Kazuyuki Fujihara a, Yusuke Suzuki a, Minami Tagawa a, Yoshiyuki Aoyama, Noriko Sakurai, Miho Yamaguchi, Kosuke Narita, , Koichi Ujita, Yuki Sakai, Jin Narumoto, Naruhito Hironaga, Shozo Tobimatsu, Jamie Near d, and Masato Fukuda
  • Organizer: 19th International Conference on Biomagnetism
  • Place of Presentation: Halifax, Canada
  • Year and Date: 2014-08-27
• [Presentation] The relationship between neurotransmitters and neural oscillation during resting state: a combined magnetic resonance spectroscopy and magnetoencephalography study (2014)
  • Author(s): Yuichi Takei, Kazuyuki Fujihara a, Yusuke Suzuki a, Minami Tagawa a, Yoshiyuki Aoyama, Noriko Sakurai, Miho Yamaguchi, Kosuke Narita, , Koichi Ujita, Yuki Sakai, Jin Narumoto, Naruhito Hironaga, Shozo Tobimatsu, Jamie Near d, and Masato Fukuda
  • Organizer: 19th International Conference on Biomagnetism
  • Place of Presentation: Halifax, Canada
  • Year and Date: 2014-08-27
• [Presentation] クロスフリークエンシーカップリングの精神疾患への応用と最近の話題 (2014)
  • Author(s): 武井雄一， 藤原和之， 田川みなみ, 笠木正人, 茂木智和, 高橋由美子, 鈴木雄介, 山口実穂， 廣永成人， 飛松省三， 成田耕介, 福田正人
  • Organizer: 第29回日本生体磁気学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-30
  • Invited
• [Presentation] Hemodynamic changes of psychiatric diseases during a face-to-face conversation
  • Author(s): Yuichi Takei, Masashi Suda, Yoshiyuki Aoyama, Kosuke Narita, Noriko Sakurai, Miho Yamaguchi, Masaki Kameyama, Masato Fukuda, Masahiko Mikuni
  • Organizer: 11th World Congress of Biological Psychiatry (WFSBP)
  • Place of Presentation: 京都
• [Presentation] 対話における脳活動から見える精神疾患の病態
  • Author(s): 武井雄一，須田真史，青山義之，成田耕介，桜井敬子，山口美穂, 亀山正樹，福田正人，三國雅彦
  • Organizer: 第42回日本臨床神経生理学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Mismatch negativity in mood disorders
  • Author(s): Yuichi Takei, Sumie Kurita, Suguru Hattori, Yuki Kawakubo, Kiyoto Kasai, Masato Fukuda, Masahiko Mikuni
  • Organizer: The Sixth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Application
  • Place of Presentation: ニューヨーク
  • Invited
• [Book] 神経生理検査 (MEG), 脳磁図からみる疾患． In：『精神疾患の脳画像ケースカンファレンス』 (2014)
  • Author(s): 武井雄一，管心, 笠井清登, 鈴木道雄, 三村 將, 村井俊哉, 福田正人.
  • Total Pages: 360
  • Publisher: 中山書店
• [Book] 精神疾患・心理現象への応用とうつ症状の先進医療．In：酒谷薫 監修・岡田英史，星詳子，宮井一郎，渡辺英寿 編集『NIRS－基礎と臨床』，pp.148-160. (2012)
  • Author(s): 福田正人，須田真史，武井雄一，青山義之
  • Total Pages: 12
  • Publisher: 新興医学出版社
• [Book] 脳磁図（MEG）の精神疾患診断への応用．In：三國雅彦，福田正人，功刀浩 編集『精神疾患診断のための脳形態・機能検査法』，pp.161-174. (2012)
  • Author(s): 武井雄一，管心，栗田澄江，笠井清登，福田正人，三國雅彦
  • Total Pages: 13
  • Publisher: 新興医学出版社
• [Remarks] 群馬大学大学院医学系研究科医学部医学科 高次機能統御系脳神経発達統御学 神経精神医学
  • URL: http://www.med.gunma-u.ac.jp/med-organization/neurosci/neurosci-development/111.html/#research
• [Remarks] 群馬大学大学院医学系研究科医学部医学科 高次機能統御系脳神経発達統御学 神経精神医学
  • URL: http://www.med.gunma-u.ac.jp/med-organization/neurosci/neurosci-development/111.html/#research