Research on brain pathological change and identification of predicting factors of developing schizophrenia,

• Project/Area Number: 24791200
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: SUGA Motomu 東京大学, 医学部附属病院, 助教 (20553704)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 統合失調症 / At Risk Mental State / 神経画像 / 生体内物質 / 予後予測 / At Risk Mental State / アットリスク状態 / マルチモダリティ神経画像 / 神経心理

Research Abstract

We performed neuro-imaging tests including magnetic resonance imaging, electroencephalography, and near infrared spectroscopy. We also conducted neuro-cognitive test battery (Brief Assessment of Cognition in Schizophrenia-Japanese version), and collected blood samples from patients with schizophrenia.
We found that neuro-imaging tests especially NIRS could be a predicting marker, and that plasma metabolites are candidate markers to improve the determination of diagnosis, severity and clinical stages, especially for schizophrenia.

Research Products

• [Journal Article] Genetic influences on prefrontal activation during a verbal fluency task in adults : A twin study based on multichannel near-infrared spectroscopy (2014)
  • Author(s): Sakakibara E, Takizawa R, Nishimura Y, Kawasaki S, Satomura Y, Kinoshita A, Koike S, Marumo K, Kinou M, Tochigi M, Nishida N, Tokunaga K, Eguchi S, Yamasaki S, Natsubori T, Iwashiro N, Inoue H, Takano Y, Takei K, Suga M, Yamasue H, Matsubayashi J, Kohata K, Shimojo C, Okuhata S, Kono T, Kuwabara H, Ishii-Takahashi A, Kawakubo Y, Kasai K
  • Journal Title: Neuroimage Volume: 1 Pages: 508-17
• [Journal Article] A snapshot of plasma metabolites in first-episode schizophrenia : A capillary electrophoresis time-of-flight mass spectrometry study (2014)
  • Author(s): Shinsuke Koike, Miki Bundo, Kazuya Iwamoto, Motomu Suga, Hitoshi Kuwabara, Yoshiaki Ohashi, Kosaku Shinoda, Yosuke Takano, Norichika Iwashiro, Yoshihiro Satomura, Tatsuya Nagai, Tatsunobu Natsubori, Mariko Tada, Hidenori Yamasue, Kiyoto Kasai
  • Journal Title: Translational Psychiatry Volume: (in press)
• [Journal Article] Neural correlate of autistic-like traits and a common allele in the oxytocin receptor gene. (2014)
  • Author(s): Yuki Saito, Motomu Suga, Mamoru Tochigi, Osamu Abe, Noriaki Yahata, Yuki Kawakubo, Xiaoxi Liu, Yoshiya Kawamura, Tsukasa Sasaki, Kiyoto Kasai, and Hidenori Yamasue
  • Journal Title: Social Cognitive and Affective Neuroscience Volume: in press
  • Peer Reviewed
• [Journal Article] A snapshot of plasma metabolites in first-episode schizophrenia: A capillary electrophoresis time-of-flight mass spectrometry study. (2014)
  • Author(s): Shinsuke Koike, Miki Bundo, Kazuya Iwamoto, Motomu Suga, Hitoshi Kuwabara, Yoshiaki Ohashi, Kosaku Shinoda, Yosuke Takano, Norichika Iwashiro, Yoshihiro Satomura, Tatsuya Nagai, Tatsunobu Natsubori, Mariko Tada, Hidenori Yamasue, Kiyoto Kasai
  • Journal Title: Translational Psychiatry Volume: in press
  • Peer Reviewed
• [Journal Article] A multimodal approach to investigate biomarkers for psychosis in a clinical setting : The integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project (2013)
  • Author(s): Koike S, Takano Y, Iwashiro N, Satomura Y, Suga M, Nagai T, Natsubori T, Tada M, Nishimura Y, Yamasaki S, Takizawa R, Yahata N, Araki T, Yamasue H, Kasai K
  • Journal Title: Schizophr Res Volume: 143(1) Pages: 116-24
• [Journal Article] 統合失調症認知機能簡易評価尺度日本語版(BACS-J)標準化の試み (2013)
  • Author(s): 兼田康宏ら, 管心
  • Journal Title: 精神医学 Volume: 55(2) Pages: 167-175
• [Journal Article] Development of brief versions of the Wechsler Intelligence Scale for schizophrenia : considerations of the structure and predictability of intelligence (2013)
  • Author(s): Chika Sumiyoshi, Miki Uetsuki, Motomu Suga, Kiyoto Kasai, Tomiki Sumiyoshi
  • Journal Title: Psychiatry Research Volume: 210(3) Pages: 773-9
• [Journal Article] A multimodal approach to investigate biomarkers for psychosis in a clinical setting: the integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project (2013)
  • Author(s): Koike, S., Takano, Y., Iwashiro, N., Satomura, Y., Suga, M., Nagai, T., Natsubori, T., Tada, M., Nishimura, Y., Yamasaki, S., Takizawa, R., Yahata, N., Araki, T., Yamasue, H. & Kasai, K
  • Journal Title: Schizophr Res Volume: 143(1) Issue: 1 Pages: 116-24
  • DOI: 10.1016/j.schres.2012.11.012
  • Peer Reviewed
• [Journal Article] Genetic influences on prefrontal activation during a verbal fluency task in adults: A twin study based on multichannel near-infrared spectroscopy. (2013)
  • Author(s): Sakakibara E, （途中19名）, Yamasue H, （以下9名）
  • Journal Title: Neuroimage Volume: Advanced online publication Pages: 508-517
  • DOI: 10.1016/j.neuroimage.2013.03.052
  • Peer Reviewed
• [Journal Article] Development of brief versions of the Wechsler Intelligence Scale for schizophrenia: considerations of the structure and predictability of intelligence (2013)
  • Author(s): Sumiyoshi C1, Uetsuki M, Suga M, Kasai K, Sumiyoshi T.
  • Journal Title: Psychiatry Research Volume: 210 Issue: 3 Pages: 773-779
  • DOI: 10.1016/j.psychres.2013.08.024
  • Peer Reviewed
• [Journal Article] Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia (2012)
  • Author(s): Iwashiro, N., Suga, M., Takano, Y., Inoue, H., Natsubori, T., Satomura, Y., Koike, S., Yahata, N., Murakami, M., Katsura, M., Gonoi, W., Sasaki, H., Takao, H., Abe, O., Kasai, K. & Yamasue, H
  • Journal Title: Schizophr Res Volume: 137(1-3) Issue: 1-3 Pages: 124-31
  • DOI: 10.1016/j.schres.2012.02.024
  • Peer Reviewed
• [Journal Article] Neural correlate of autistic-like traits and a common allele in the oxytocin receptor gene
  • Author(s): Yuki Saito, Motomu Suga, Mamoru Tochigi, Osamu Abe, Noriaki Yahata, Yuki Kawakubo, Xiaoxi Liu, Yoshiya Kawamura, Tsukasa Sasaki, Kiyoto Kasai, and Hidenori Yamasue
  • Journal Title: Social Cognitive and Affective Neuroscience Volume: (in press)
• [Presentation] 知能の縦断的評価WAIS-R とWISC-R の対応 (2014)
  • Author(s): 住吉チカ, 植月美希, 管心, 笠井清登, 住吉太幹
  • Organizer: 日本発達心理学会第25回
  • Place of Presentation: 京都大学百周年記念館
• [Presentation] 知能の縦断的評価WAIS-RとWISC-Rの対応 (2014)
  • Author(s): 住吉チカ、植月美希、管心、笠井清登、住吉太幹
  • Organizer: 第25回日本発達心理学会
  • Place of Presentation: 京都
• [Presentation] 音声言語課題を用いた統合失調症における脳磁場反応の検討 (2013)
  • Author(s): 管心, 川久保友紀, 西村幸香, 湯本真人, 伊藤憲治, 笠井清登
  • Organizer: 第28回日本生体磁気学会 シンポジウム
  • Place of Presentation: 新潟
  • Year and Date: 2013-06-08
• [Presentation] 近赤外線スペクトロスコピィを用いた統合失調症の予後予測と状態像把握 (2013)
  • Author(s): 小池進介, ら
  • Organizer: 第109回日本精神神経学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2013-05-24
• [Presentation] ARMS の生物学的指標は臨床場面に応用できるのか (2013)
  • Author(s): 小池進介, ら
  • Organizer: 第109回日本精神神経学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2013-05-23
• [Presentation] 統合失調症の早期段階における脳波ガンマ帯域反応と臨床症状, 認知機能障害との関連 (2013)
  • Author(s): 多田真理子, 永井達哉, 切原賢治, 荒木剛, 小池進介, 管心, 笠井清登
  • Organizer: 第8回日本統合失調症学会
  • Place of Presentation: 浦河
• [Presentation] 精神病性障害の早期段階におけるミスマッチ陰性電位と血中D-serine 濃度の関連 : 予備的検討 (2013)
  • Author(s): 永井達哉, 多田真理子, 切原賢治, 小池進介, 管心, 荒木剛, 橋本龍一郎, 八幡憲明, 橋本謙二, 笠井清登
  • Organizer: 第8回日本統合失調症学会
  • Place of Presentation: 浦河
• [Presentation] 初回エピソード統合失調症における末梢血血漿成分のメタボロミクス解析 (2013)
  • Author(s): 小池進介, 岩本和也, 文東美紀, 高野洋輔, 岩白訓周, 里村嘉弘, 永井達哉, 多田真理子, 夏堀龍暢, 管心, 笠井清登
  • Organizer: 第8回日本統合失調症学会
  • Place of Presentation: 浦河
• [Presentation] Development of brief versions of the Wechsler Intelligence Scale for schizophrenia (2013)
  • Author(s): Sumiyoshi, Chika, Uetsuki, Miki, Suga Motomu, Kasai Kiyoto, Sumiyoshi Tomiki
  • Organizer: The 14th International Congress on Schizophrenia Research
  • Place of Presentation: Florida
• [Presentation] 統合失調症の発症後における下前頭回三角部の皮質体積減少と神経活動低下との関連 (2013)
  • Author(s): 岩白訓周, 小池進介, 管心, 夏堀龍暢, 滝澤龍, 五丿井渉, 阿部修, 國松聡, 山末英典, 笠井清登
  • Organizer: 第17回日本精神保健・予防学会
  • Place of Presentation: 東京
• [Presentation] 音声言語課題を用いた統合失調症における脳磁場反応の検討 (2013)
  • Author(s): 管心、川久保友紀、西村幸香、湯本真人、伊藤憲治、笠井清登
  • Organizer: 第28回日本生体磁気学会
  • Place of Presentation: 新潟
  • Invited
• [Presentation] 統合失調症の早期段階における脳波ガンマ帯域反応と臨床症状、認知機能障害との関連 (2013)
  • Author(s): 多田真理子、永井達哉、切原賢治、荒木剛、小池進介、管心、笠井清登
  • Organizer: 第8回日本統合失調症学会
  • Place of Presentation: 浦河
• [Presentation] 精神病性障害の早期段階におけるミスマッチ陰性電位と血中D-serine 濃度の関連：予備的検討 (2013)
  • Author(s): 永井達哉、多田真理子、切原賢治、小池進介、管心、荒木剛、橋本龍一郎、八幡憲明、橋本謙二、笠井清登
  • Organizer: 第8回日本統合失調症学会
  • Place of Presentation: 浦河
• [Presentation] Development of brief versions of the Wechsler Intelligence Scale for schizophrenia. (2013)
  • Author(s): Sumiyoshi, Chika, Uetsuki, Miki, Suga Motomu, Kasai Kiyoto, Sumiyoshi Tomiki
  • Organizer: The 14th International Congress on Schizophrenia Research
  • Place of Presentation: Florida
• [Presentation] ARMSの生物学的指標は臨床場面に応用できるのか (2013)
  • Author(s): 小池進介ら
  • Organizer: 第109回日本精神神経学会学術集会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 初発統合失調症群と精神病状態の高リスク群に共通して認められる下前頭回における三角部に限局した灰白質体積減少とその陽性症状発現との関連 (2012)
  • Author(s): 岩白訓周, 管心, ら
  • Organizer: 第7回日本統合失調症学会
  • Place of Presentation: 名古屋
• [Presentation] 初回エピソード統合失調症における語流暢性課題を用いた近赤外線スペクトロスコピィによる血流変化の縦断的変化と社会機能の予測 (2012)
  • Author(s): 小池進介, ら
  • Organizer: 第7回日本統合失調症学会
  • Place of Presentation: 名古屋
• [Presentation] 双生児研究法による近赤外線スペクトロスコピーの前頭側頭部血流変化における遺伝的要因の検討 (2012)
  • Author(s): 榊原英輔, ら
  • Organizer: 第7回日本統合失調症学会
  • Place of Presentation: 名古屋
• [Presentation] 統合失調症認知評価尺度を用いた精神病発症前後における予後予測因子の検討 (2012)
  • Author(s): 管心, 小池進介, 高野洋輔, 里村嘉弘, 岩白訓周, 多田真理子, 夏堀龍暢, 永井達哉, 江口聡, 下條千恵, 山崎修道, 荒木剛, 笠井清登
  • Organizer: 第7回日本統合失調症学会
  • Place of Presentation: 名古屋
• [Book] 精神保健サービス実践ガイド (2012)
  • Author(s): G・ソーニクロフト, M・タンセラ著, 岡崎祐士, 笠井清登, 福田正人, 近藤伸介監訳
  • Publisher: 日本評論社
• [Book] 精神保健サービス実践ガイド (2012)
  • Author(s): G・ソーニクロフト、M・タンセラ著、岡崎祐士、笠井清登、福田正人、近藤伸介監訳
  • Total Pages: 249
  • Publisher: 日本評論社
• [Remarks] こころのリスク外来
  • URL: http://plaza.umin.ac.jp/arms-ut/
• [Remarks] こころのリスク外来
  • URL: http://plaza.umin.ac.jp/arms-ut/