The long-term effect of Methylphenidate on brain function of ADHD children after wash-out period

• Project/Area Number: 24791201
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: ISHII-TAKAHASHI Ayaka 東京大学, 医学部附属病院, 助教 (40609020)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ADHD / 光トポグラフィー / 塩酸メチルフェニデート / 注意欠如多動性障害 / 近赤外線スペクトロスコピイ

Research Abstract

Methylphenidate (MPH) is the most commonly prescribed treatment for Attention Deficit-Hyperactivity Disorder (ADHD). Near-infrared spectroscopy (NIRS) is a noninvasive neuroimaging method that can measure hemodynamic changes in cortical tissue under natural settings. The stop signal task is suitable for detecting dysfunction of response inhibition in ADHD. In this study we aim to detect the long-term effect of MPH on brain function of ADHD children after wash-out period using NIRS during SST. Drug naive ADHD group had lower NIRS signal than healthy control in baseline assessment. However even after MPH washout following a 1-year administration, NAÏVE demonstrated normalised prefrontal activation. Thus, supplementary NIRS serves as an objective biomarker for clinical decisions concerning to stop MPH treatment in children with ADHD.

Research Products

• [Journal Article] on behalf of the Joint Project for Psychiatric Application of Near-Infrared Spectroscopy (JPSY-NIRS) Group. (Ishii-Takahashi A) Neuroimaging-aided differential diagnosis of the depressive state (2014)
  • Author(s): Takizawa R, Fukuda M, Kawasaki S, Kasai K, Mimura M, Pu S, Noda T, Niwa SI, Okazaki Y
  • Journal Title: Neuroimage Volume: 15:85 Pages: 498-507
  • Peer Reviewed
• [Journal Article] Genetic influences on prefrontal activation during a verbal fluency task in adults : A twin study based on multichannel near-infrared spectroscopy (2014)
  • Author(s): Sakakibara E, Takizawa R, Nishimura Y, Kawasaki S, Satomura Y, Kinoshita A, Koike S, Marumo K, Kono T, Kuwabara H, Ishii-Takahashi A, Kawakubo Y, Kasai K
  • Journal Title: Neuroimage Volume: 85:1 Pages: 508-17
  • Peer Reviewed
• [Journal Article] Multimodal imaging from Infancy to adolescence illustrating typical and atypical brain development (2014)
  • Author(s): 石井礼花
  • Journal Title: 日本生物学的精神医学会誌 Volume: (in press)
  • NAID: 130005395432
• [Journal Article] Neuroimaging-aided differential diagnosis of the depressive state (2014)
  • Author(s): Takizawa R, Fukuda M, Kawasaki S, Kasai K, Mimura M, Pu S, Noda T, Niwa S, Okazaki Y; Joint Project for Psychiatric Application of Near-Infrared Spectroscopy (JPSY-NIRS) Group.
  • Journal Title: Neuroimage Volume: 85 Pages: 498-507
  • DOI: 10.1016/j.neuroimage.2013.05.126
  • Peer Reviewed
• [Journal Article] Prefrontal activation during inhibitory control measured by near-infrared spectroscopy for differentiating between autism spectrum disorders and attention deficit hyperactivity disorder in adults (2013)
  • Author(s): Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Matsubayashi J, Hamada K, Okuhata S, Yahata N, Igarashi T, Kawasaki S, Yamasue H, Kato N, Kasai K, Kano Y
  • Journal Title: Neuroimage clinical Volume: 4 Pages: 53-63
  • Peer Reviewed
• [Journal Article] Genetic influences on prefrontal activation during a verbal fluency task in adults: A twin study based on multichannel near-infrared spectroscopy. (2013)
  • Author(s): Sakakibara E, （途中19名）, Yamasue H, （以下9名）
  • Journal Title: Neuroimage Volume: Advanced online publication Pages: 508-517
  • DOI: 10.1016/j.neuroimage.2013.03.052
  • Peer Reviewed
• [Journal Article] Prefrontal activation during inhibitory control measured by near-infrared spectroscopy for differentiating between autism spectrum disorders and attention deficit hyperactivity disorder in adults (2013)
  • Author(s): Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Kuwabara H, Matsubayashi J, Hamada K, Okuhata S, Yahata N, Igarashi T, Kawasaki S, Yamasue H, Kato N, Kasai K, and Kano Y
  • Journal Title: Neuroimage : Clinical Volume: 4 Pages: 53-63
  • DOI: 10.1016/j.nicl.2013.10.002
  • Peer Reviewed
• [Journal Article] 多動、落ち着きがない幼児への対応 (2012)
  • Author(s): 石井礼花
  • Journal Title: 小児科学レクチャー Volume: 2巻6号
• [Presentation] Prefrontal activation during inhibitory control measured by near-infrared spectroscopy for differentiating between autism spectrum disorders and attention deficit hyperactivity disorder in adults (2014)
  • Author(s): Ishii-Takahashi A
  • Organizer: The second Asian ADHD congress
  • Place of Presentation: Tokyo Japan
• [Presentation] Neuroimaging-aided prediction of the effect of methylphenidate in children with attention deficit hyperactivity disorder-a randomised controlled trial (2014)
  • Author(s): Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Matsubayashi J, Hamada K, Okuhata S, Igarashi T, Kawasaki S, Yamasue H, Kato N, Kasai K, Kano Y
  • Organizer: 69th Society of biological psychiatry
• [Presentation] near-infrared spectroscopy for differentiating between autism spectrum disorders and attention deficit hyperactivity disorder in adults. (2014)
  • Author(s): Ishii-Takahashi A.
  • Organizer: The second Asian ADHD congress
  • Place of Presentation: 東京、日本
  • Invited
• [Presentation] Neuroimaging-aided prediction of the effect of methylphenidate in children with attention deficit hyperactivity disorder―a randomised controlled trial (2014)
  • Author(s): Ishii-Takahashi A.
  • Organizer: 69th Society of bological psychiatry
  • Place of Presentation: New York, USA
• [Presentation] The long-term effect of methylphenidate on brain function of ADHD children after wash-out (2013)
  • Author(s): Ishii-Takahashi A
  • Organizer: The world federation of biological psychiatry
  • Place of Presentation: Kyoto Japan
• [Presentation] The long-term effect of methylphenidate on brain function of ADHD children after wash-out. (2013)
  • Author(s): Ishii-Takahashi A.
  • Organizer: The world federation of biological psychiatry
  • Place of Presentation: 京都、日本
  • Invited
• [Presentation] The long-term effect ofmethylphenidate on brain function of ADHD children after wash-out (2013)
  • Author(s): Ayaka Ishii-Takahashi
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto Japan
  • Invited
• [Presentation] The long-term effect of methylphenidate on brain function of ADHD children after wash-out (2012)
  • Author(s): Ishii-Takahashi A
  • Organizer: The 1st Asian Congress On ADHD
  • Place of Presentation: Seul South Korea
• [Presentation] The long-term effect ofmethylphenidate on brain function of ADHD children after wash-out (2012)
  • Author(s): Ayaka Ishii-Takahashi
  • Organizer: The 1st Asian Congress On ADHD
  • Place of Presentation: Seul South Korea
  • Invited
• [Book] 「中枢神経興奮薬・抗うつ薬など, 精神安定薬脳循環, 代謝改善薬」新小児薬用量 (2012)
  • Author(s): 石井礼花
  • Publisher: 診断と治療社
• [Book] 「発達障害」「自閉症スペクトラム」「注意欠陥多動性障害」子どもの病気ナビゲーター (2012)
  • Author(s): 石井礼花
  • Publisher: メディカルレビュー社
• [Book] 新小児薬用量 (2012)
  • Author(s): 石井礼花
  • Total Pages: 14
  • Publisher: 診断と治療社
• [Book] 子どもの病気ナビゲーター (2012)
  • Author(s): 石井礼花
  • Total Pages: 3
  • Publisher: メディカルレビュー社