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The long-term effect of Methylphenidate on brain function of ADHD children after wash-out period

Research Project

Project/Area Number 24791201
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionThe University of Tokyo

Principal Investigator

ISHII-TAKAHASHI Ayaka  東京大学, 医学部附属病院, 助教 (40609020)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsADHD / 光トポグラフィー / 塩酸メチルフェニデート / 注意欠如多動性障害 / 近赤外線スペクトロスコピイ
Research Abstract

Methylphenidate (MPH) is the most commonly prescribed treatment for Attention Deficit-Hyperactivity Disorder (ADHD). Near-infrared spectroscopy (NIRS) is a noninvasive neuroimaging method that can measure hemodynamic changes in cortical tissue under natural settings. The stop signal task is suitable for detecting dysfunction of response inhibition in ADHD. In this study we aim to detect the long-term effect of MPH on brain function of ADHD children after wash-out period using NIRS during SST. Drug naive ADHD group had lower NIRS signal than healthy control in baseline assessment. However even after MPH washout following a 1-year administration, NAÏVE demonstrated normalised prefrontal activation. Thus, supplementary NIRS serves as an objective biomarker for clinical decisions concerning to stop MPH treatment in children with ADHD.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (21 results)

All 2014 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (9 results) (of which Invited: 4 results) Book (4 results)

  • [Journal Article] on behalf of the Joint Project for Psychiatric Application of Near-Infrared Spectroscopy (JPSY-NIRS) Group. (Ishii-Takahashi A) Neuroimaging-aided differential diagnosis of the depressive state2014

    • Author(s)
      Takizawa R, Fukuda M, Kawasaki S, Kasai K, Mimura M, Pu S, Noda T, Niwa SI, Okazaki Y
    • Journal Title

      Neuroimage

      Volume: 15:85 Pages: 498-507

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic influences on prefrontal activation during a verbal fluency task in adults : A twin study based on multichannel near-infrared spectroscopy2014

    • Author(s)
      Sakakibara E, Takizawa R, Nishimura Y, Kawasaki S, Satomura Y, Kinoshita A, Koike S, Marumo K, Kono T, Kuwabara H, Ishii-Takahashi A, Kawakubo Y, Kasai K
    • Journal Title

      Neuroimage

      Volume: 85:1 Pages: 508-17

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multimodal imaging from Infancy to adolescence illustrating typical and atypical brain development2014

    • Author(s)
      石井礼花
    • Journal Title

      日本生物学的精神医学会誌

      Volume: (in press)

    • NAID

      130005395432

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Neuroimaging-aided differential diagnosis of the depressive state2014

    • Author(s)
      Takizawa R, Fukuda M, Kawasaki S, Kasai K, Mimura M, Pu S, Noda T, Niwa S, Okazaki Y; Joint Project for Psychiatric Application of Near-Infrared Spectroscopy (JPSY-NIRS) Group.
    • Journal Title

      Neuroimage

      Volume: 85 Pages: 498-507

    • DOI

      10.1016/j.neuroimage.2013.05.126

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prefrontal activation during inhibitory control measured by near-infrared spectroscopy for differentiating between autism spectrum disorders and attention deficit hyperactivity disorder in adults2013

    • Author(s)
      Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Matsubayashi J, Hamada K, Okuhata S, Yahata N, Igarashi T, Kawasaki S, Yamasue H, Kato N, Kasai K, Kano Y
    • Journal Title

      Neuroimage clinical

      Volume: 4 Pages: 53-63

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic influences on prefrontal activation during a verbal fluency task in adults: A twin study based on multichannel near-infrared spectroscopy.2013

    • Author(s)
      Sakakibara E, (途中19名), Yamasue H, (以下9名)
    • Journal Title

      Neuroimage

      Volume: Advanced online publication Pages: 508-517

    • DOI

      10.1016/j.neuroimage.2013.03.052

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prefrontal activation during inhibitory control measured by near-infrared spectroscopy for differentiating between autism spectrum disorders and attention deficit hyperactivity disorder in adults2013

    • Author(s)
      Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Kuwabara H, Matsubayashi J, Hamada K, Okuhata S, Yahata N, Igarashi T, Kawasaki S, Yamasue H, Kato N, Kasai K, and Kano Y
    • Journal Title

      Neuroimage : Clinical

      Volume: 4 Pages: 53-63

    • DOI

      10.1016/j.nicl.2013.10.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 多動、落ち着きがない幼児への対応2012

    • Author(s)
      石井礼花
    • Journal Title

      小児科学レクチャー

      Volume: 2巻6号

    • Related Report
      2012 Research-status Report
  • [Presentation] Prefrontal activation during inhibitory control measured by near-infrared spectroscopy for differentiating between autism spectrum disorders and attention deficit hyperactivity disorder in adults2014

    • Author(s)
      Ishii-Takahashi A
    • Organizer
      The second Asian ADHD congress
    • Place of Presentation
      Tokyo Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Neuroimaging-aided prediction of the effect of methylphenidate in children with attention deficit hyperactivity disorder-a randomised controlled trial2014

    • Author(s)
      Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Matsubayashi J, Hamada K, Okuhata S, Igarashi T, Kawasaki S, Yamasue H, Kato N, Kasai K, Kano Y
    • Organizer
      69th Society of biological psychiatry
    • Related Report
      2013 Final Research Report
  • [Presentation] near-infrared spectroscopy for differentiating between autism spectrum disorders and attention deficit hyperactivity disorder in adults.2014

    • Author(s)
      Ishii-Takahashi A.
    • Organizer
      The second Asian ADHD congress
    • Place of Presentation
      東京、日本
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Neuroimaging-aided prediction of the effect of methylphenidate in children with attention deficit hyperactivity disorder―a randomised controlled trial2014

    • Author(s)
      Ishii-Takahashi A.
    • Organizer
      69th Society of bological psychiatry
    • Place of Presentation
      New York, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] The long-term effect of methylphenidate on brain function of ADHD children after wash-out2013

    • Author(s)
      Ishii-Takahashi A
    • Organizer
      The world federation of biological psychiatry
    • Place of Presentation
      Kyoto Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] The long-term effect of methylphenidate on brain function of ADHD children after wash-out.2013

    • Author(s)
      Ishii-Takahashi A.
    • Organizer
      The world federation of biological psychiatry
    • Place of Presentation
      京都、日本
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The long-term effect ofmethylphenidate on brain function of ADHD children after wash-out2013

    • Author(s)
      Ayaka Ishii-Takahashi
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto Japan
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] The long-term effect of methylphenidate on brain function of ADHD children after wash-out2012

    • Author(s)
      Ishii-Takahashi A
    • Organizer
      The 1st Asian Congress On ADHD
    • Place of Presentation
      Seul South Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] The long-term effect ofmethylphenidate on brain function of ADHD children after wash-out2012

    • Author(s)
      Ayaka Ishii-Takahashi
    • Organizer
      The 1st Asian Congress On ADHD
    • Place of Presentation
      Seul South Korea
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 「中枢神経興奮薬・抗うつ薬など, 精神安定薬脳循環, 代謝改善薬」新小児薬用量2012

    • Author(s)
      石井礼花
    • Publisher
      診断と治療社
    • Related Report
      2013 Final Research Report
  • [Book] 「発達障害」「自閉症スペクトラム」「注意欠陥多動性障害」子どもの病気ナビゲーター2012

    • Author(s)
      石井礼花
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Final Research Report
  • [Book] 新小児薬用量2012

    • Author(s)
      石井礼花
    • Total Pages
      14
    • Publisher
      診断と治療社
    • Related Report
      2012 Research-status Report
  • [Book] 子どもの病気ナビゲーター2012

    • Author(s)
      石井礼花
    • Total Pages
      3
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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