Association study of schizophrenia by focusing on non-coding RNAs and their target genes responding to psychotomimetic drugs.

Research Project

Project/Area Number	24791202
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Psychiatric science
Research Institution	Tokyo Medical and Dental University
Principal Investigator	JITOKU Daisuke 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (10613854)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	遺伝子研究 / 統合失調症 / ヒストン / マイクロRNA / 関連解析 / グルタミン酸
Outline of Final Research Achievements	We focused on microRNAs responding to schizophrenomimetic glutamate receptor antagonist and examined their target genes. The subjects were a Japanese cohort (2,000 patients with schizophrenia and 2,000 control subjects). As the result, we detected a significant association between H-Z gene (histone-associatied gene) and the male patients with schizophrenia. The present findings suggest that modification of the H-Z gene signaling pathway warrants further study in terms of the pathophysiology of schizophrenia.

Report

(4 results)