Association study of schizophrenia by focusing on non-coding RNAs and their target genes responding to psychotomimetic drugs.

• Project/Area Number: 24791202
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: JITOKU Daisuke 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (10613854)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 遺伝子研究 / 統合失調症 / ヒストン / マイクロRNA / 関連解析 / グルタミン酸

Outline of Final Research Achievements

We focused on microRNAs responding to schizophrenomimetic glutamate receptor antagonist and examined their target genes. The subjects were a Japanese cohort (2,000 patients with schizophrenia and 2,000 control subjects). As the result, we detected a significant association between H-Z gene (histone-associatied gene) and the male patients with schizophrenia. The present findings suggest that modification of the H-Z gene signaling pathway warrants further study in terms of the pathophysiology of schizophrenia.

Research Products

• [Journal Article] Association study of H2AFZ with schizophrenia in a Japanese case-control sample. (2014)
  • Author(s): Jitoku D, Yamamoto N, Iwayama Y, Toyota T, Miyagi M, Enokida T, Tasaka Y, Umino M, Umino A, Uezato A, Iwata Y, Suzuki K, Kikuchi M, Hashimoto T, Kanahara N, Kurumaji A, Yoshikawa T, Nishikawa T.
  • Journal Title: Journal of Neural Transmission Volume: 11 Issue: 6 Pages: 1-9
  • DOI: 10.1007/s00702-014-1332-x
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] H2AFZ遺伝子と統合失調症との遺伝子関連研究 (2014)
  • Author(s): 治徳 大介, 山本 直樹, 岩山 佳美, 上里 彰仁, 吉川 武男, 車地 暁生, 西川 徹
  • Organizer: 第36回日本生物学的精神医学会 / 第57回日本神経化学会大会 合同年会
  • Place of Presentation: 奈良
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] Association study of H2AFZ with schizophrenia in a Japanese case-control sample. (2014)
  • Author(s): Daisuke Jitoku, Naoki Yamamoto, Yoshimi Iwayama, Masakazu Umino, Asami Umino, Akihito Uezato, Akeo Kurumaji, Takeo Yoshikawa, and Toru Nishikawa.
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: バンクーバー
  • Year and Date: 2014-06-22 – 2014-06-26