The role of incretins in atypical antipsychotic-induced obesity
| Project/Area Number |
24791204
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Niigata University |
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Principal Investigator |
ONO Shin 新潟大学, 医歯(薬)学総合研究科, 非常勤講師 (60623402)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 抗精神病薬 / 統合失調症 / 糖代謝異常 / 体重増加 / 薬理遺伝 / インクレチン |
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| Outline of Final Research Achievements |
We investigated the mechanism of glucose metabolism and weight gain due to atypical antipsychotics. The prevalence of abnormal glucose tolerance in schizophrenia was examined. Among patients with normal fasting glucose, 17.3% had impaired glucose tolerance, and 1.3% were diagnosed with diabetes. Association between glucose-dependent insulinotropic polypeptide (GIP) receptor polymorphism and body mass index in olanzapine-treated schizophrenia was examined. GIPR polymorphism may predict weight gain in schizophrenia. The GIP concentration was measured at two types of antipsychotics. AUC-GIP was higher in oral administration of aripiprazole and quetiapine than in naive. Antipsychotics might affect on increased incretin secretion.
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Report
(4 results)
Research Products
(21 results)
