| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We found that SSRI and dopamine partial agonist aripiprazole have distinct effects on the regulations of synaptic proteins in the rat nucleus accumbens after chronic stress. To investigate if we could predict the responses to chronic unpredictable stress of each individual based on the pre-stress individual differences, we next aimed to classify several subgroups from naive rats based on their performance of food-instrumental training with progressive ratio schedule. We succeeded to classify 4 from a group of original naive into 4 subgroups that represent distinctive response in motivation or reactions in cost/benefit decision-making. In addition, each 4 subgroups demonstrated distinct phenotypes after 3-weeks chronic unpredictable stress. These data implicate that the phenotypes induced after chronic stress in rats largely depend on individual differences that exist at pre-stress stages, and it would be possible to predict the responses to stress of each by taking advantage of it.
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