| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
The Bcl-2 family members have essential roles in apoptosis. It is reported that Bcl-2 family contribute to stress-induced depression-like behavior. In this study, we investigated the expression of BH3-only protein mRNA in the brain of the animal model for depression. The expression of Noxa in the hippocampus was significantly increased. In non-stressed condition, Noxa KO mice showed longer time of social interaction compared to wild-type mice. With social defeat stress, wild-type mice showed a reduced social interaction time, whereas Noxa KO mice did not show such reduction of social interaction time. These results suggested that Noxa might relate to the stress vulnerability.
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