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Developmental neuro-scientific study on the functional connectivity hypothesis of ASD

Research Project

Project/Area Number 24791218
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionNagasaki University

Principal Investigator

DOI Hirokazu  長崎大学, 医歯(薬)学総合研究科, 講師 (40437827)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsASD / 機能的連関 / 遺伝子多型 / 脳波 / 発達障害 / 自閉症スペクトラム障害 / 乳児
Research Abstract

It is well-established that early intervention to children with autism-spectrum disorders greatly improves their later adaptation to the social world.Recent studies show that some of core symptoms of autism-spectrum disorders is attributable to the impairment of the functional connectivity in the neural system. On the basis of this, it might be possible to develop an early screening measure by quantifying the functional connectivity from infants EEG. To this end, an exploratory investigation was conducted on what kind of EEG measurement paradigm is suitable for the measurement of infants functional connectivity. The preset study also investigated a biological marker linked to infants social communication ability that can improve the screening accuracy when used conjointly with the functional connectivity measure. The results have shown a trend-level significance in the relation between visual attention towards social stimuli and the genotype of neurotransmitter-related gene.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 Other

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] 注意の生理学的指標2014

    • Author(s)
      土居裕和, 篠原一之
    • Journal Title

      精神科

      Volume: 24(2) Pages: 147-153

    • Related Report
      2013 Final Research Report
  • [Journal Article] 注意の生理学的指標2014

    • Author(s)
      土居裕和、篠原一之
    • Journal Title

      精神科

      Volume: 24 Pages: 147-153

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Prenatal Exposure to a Polychlorinated Biphenyl (PCB) Congener Influences Fixation Duration on Biological Motion at 4-Months-Old : A Preliminary Study2013

    • Author(s)
      DoiH, NishitaniS, FujisawaT, NagaiT, KakeyamaM, MaedaT, ShinoharaK
    • Journal Title

      PLos ONE

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 成人ASDの表情認知・音声認知2013

    • Author(s)
      土居裕和、篠原一之
    • Journal Title

      精神科

      Volume: 21(6) Pages: 680-686

    • Related Report
      2012 Research-status Report
  • [Presentation] Prenatal exposure to polychlorinated biphenyl (PCB) congener impairs socio-cognitive ability in human four-month-olds2013

    • Author(s)
      DoiH, NishitaniS, FujisawaT, NagaiT, KakeyamaM, MaedaT, ShinoharaK
    • Organizer
      11th WFSBP
    • Place of Presentation
      kyoto, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Prenatal exposure to polychlorinated biphenyl (PCB) congener impairs socio-cognitive ability in human four-month-olds2013

    • Author(s)
      Doi H, Nishitani S, Fujisawa T, Nagai T, Kakeyama M, Maeda T, Shinohara K
    • Organizer
      WFSBP Congress 2013
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 胎生期PCB曝露が乳児期バイオロジカルモーション知覚発達に及ぼす影響2013

    • Author(s)
      土居裕和 他
    • Organizer
      Neuro2013
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.med.nagasaki-u.ac.jp/physlgy2/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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