| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
DARPP-32, which is thought to be involved in schizophrenia, controls the protein phosphatase (PP1) and protein kinase A (PKA) in a phosphorylation-dependent manner, and its phosphorylation level is regulated by dopaminergic and glutaminergic stimulations. .
We hypothesize that Pin1 isomerizes phosphorylated DARPP-32 and controls the inhibitory activity of DARPP-32 on PP1 and PKA. We conducted biochemical analysis to examine the hypothesis. We also made in silico analysis to predict the common binding partners of DARPP-32 and Pin1.
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