The pathophysiology of obsessive-compulsive disorder revealed by multi-modal neuroimaging

• Project/Area Number: 24791223
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: TAKASHI Nakamae 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50542891)
• Research Collaborator: NISHIDA Seiji ; SAKAI Yuki
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 強迫性障害 / 核磁気共鳴画像(MRI)

Outline of Final Research Achievements

This study investigated the pathophysiology of obsessive-compulsive disorder (OCD) using multi-modal magnetic resonance imaging technique. Analysis of T1-weighted images showed reduced grey matter volumes in several brain regions including the insula in patients with OCD compared to healthy controls. Analysis of diffusion weighted images revealed abnormal topography and increased structural connectivity of white matter fibers that connect the orbitofrontal cortex and the ventral striatum in patients with OCD compared to healthy controls. These results suggested that not only fronto-strital circuits but also other brain regions including the insula are associated with pathophysiology of OCD.

Research Products

• [Journal Article] Altered Fronto-Striatal Fiber Topography and Connectivity in Obsessive-Compulsive Disorder (2014)
  • Author(s): Takashi Nakamae, Yuki Sakai, Yoshinari Abe, Seiji Nishida, Kenji Fukui, Kei Yamada, Manabu Kubota, Damiaan Denys, Jin Narumoto
  • Journal Title: PLOS ONE Volume: 9 Issue: 11 Pages: e112075-e112075
  • DOI: 10.1371/journal.pone.0112075
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Voxel-based Morphometry Multi-center Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder. (2014)
  • Author(s): de Wit SJ, Narumoto J, et al.
  • Journal Title: Am J Psychiatry Volume: 171 Issue: 3 Pages: 340-349
  • DOI: 10.1176/appi.ajp.2013.13040574
  • Peer Reviewed
• [Journal Article] 難治性強迫性障害の特徴と治療選択 (2013)
  • Author(s): 中前 貴
  • Journal Title: 精神科 Volume: 23 Pages: 207-210
• [Journal Article] 強迫性障害における認知機能障害 (2013)
  • Author(s): 中前 貴、成本 迅
  • Journal Title: 臨床精神医学 Volume: 42 Pages: 1513-1520
• [Journal Article] 安静時機能的磁気共鳴画像法：精神科臨床研究への応用 (2013)
  • Author(s): 酒井雄希、成本 迅、中前 貴、福居顯二
  • Journal Title: 精神科 Volume: 22
• [Journal Article] OCD難治例の特徴と治療選択 (2013)
  • Author(s): 中前 貴
  • Journal Title: 精神科 Volume: 23
• [Presentation] 強迫性障害における前頭皮質－線条体回路とセロトニン機能 (2014)
  • Author(s): 中前 貴
  • Organizer: 第36回日本生物学的精神医学会
  • Place of Presentation: 奈良県文化会館（奈良県奈良市）
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] 難治例に対する新たな治療法の可能性
  • Author(s): 中前 貴
  • Organizer: 第109回日本精神神経学会学術総会
  • Place of Presentation: 福岡
• [Presentation] Altered fronto-striatal fiber topography in obsessive-compulsive disorder
  • Author(s): Nakamae T, Narumoto J, Abe Y, Sakai Y, Nishida S, Yamada K, Denys D, Fukui K
  • Organizer: 7th Annual Scientific Meeting of International College of Obsessive-Compulsive Spectrum Disorders
  • Place of Presentation: バルセロナ
• [Presentation] 強迫性障害の難治例の特徴と治療選択
  • Author(s): 中前 貴
  • Organizer: 第5回日本不安障害学会学術大会
  • Place of Presentation: 札幌