Establishment of an animal model for schizophrenia based on neurodevelopmental hypothesis.
| Project/Area Number |
24791226
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 統合失調症 |
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| Research Abstract |
Schizophrenia is a severe disabling disorder of unknown etiology. The neurodevelopmental model postulates that the illness is caused by a combination of genetic factors and environmental disturbances, including prenatal infection, perinatal complication, and so on.
Animal models are indispensable tools to gain insights into mechanisms underlying this illness and to assess potential therapeutic actions of new treatments. In this study, we attempt to generate an animal model that reflects the characteristics of patients with schizophrenia using in utero electroporation. Furthermore, we examine the relationship between histological disturbance and environmental insults such as polyI:C administration.
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Report
(3 results)
Research Products
(4 results)
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[Presentation] Oligodendrocyte plasticity with an intact cell body in vitro2013
Author(s)
Makinodan M, Okuda-Yamamoto, A, Ikawa D, Toritsuka M, Tatsumi K, Okuda H, Fukami S, Yoshino H, Yamamuro K, Okumura K, Yamashita Y, Nakamura Y, Wanaka A, Kishimoto T
Organizer
The FENS Featured Regional Meeting 2013
Place of Presentation
Prague, Czech Republic
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