| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Schizophrenia is a severe disabling disorder of unknown etiology. The neurodevelopmental model postulates that the illness is caused by a combination of genetic factors and environmental disturbances, including prenatal infection, perinatal complication, and so on.
Animal models are indispensable tools to gain insights into mechanisms underlying this illness and to assess potential therapeutic actions of new treatments. In this study, we attempt to generate an animal model that reflects the characteristics of patients with schizophrenia using in utero electroporation. Furthermore, we examine the relationship between histological disturbance and environmental insults such as polyI:C administration.
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