| Project/Area Number |
24791228
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
TAKAHASHI Shun 和歌山県立医科大学, 医学部, 助教 (10508021)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 統合失調症 / GABA機能 / ２連発経頭蓋磁気刺激 / 認知機能障害 / 認知機能 / GABA |
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| Research Abstract |
We examined (1) relationship between GABAergic function and cognitive impairment in recent onset schizophrenia, (2) deterioration of GABAergic function in schizophrenia. We assessed GABAergic function using paired-pulse transcranial magnetic stimulation. The results of this study were (1) reduction of cortical GABAergic inhibition correlated with working memory impairment in the recent onset schizophrenia, and (2) cortical GABAergic inhibition was reduced in the recent onset and chronic schizophrenia, and cortical glutamatergic facilitation was increased in the chronic schizophrenia. Our results suggest that GABAergic dysfunction is related to cognitive impairment in recent onset schizophrenia and indicate that GABA/glutamatergic function is progressively disturbed in schizophrenia. These findings support the possibility of the GABA-modulating interventions for cognitive impairment in the early course of schizophrenia.
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