Examination of the neurodevelopmentally hypothesis using the prenatal glucocorticoid exposure model
| Project/Area Number |
24791229
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | グルココルチコイド / 神経ネットワーク / 海馬神経細胞 / 神経発達 / 神経分化 / 大脳白質 / シナプス形成障害 / 神経ネットワーク形成 / 細胞骨格 / 拡散テンソル画像 |
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| Research Abstract |
In this study, we analyzed the effect of prenatal glucocorticoid on the cortical formation, neuronal differentiation and neuronal network. When the primary hippocampal neuron cultured cell was given a corticosterone, caldesmon in the spain decreased it in concentration-dependency through a serum response factor and destabilized the F-actin. As a result of having analyzed neural network formation in the posterior white matter of the glucocorticoid exposed adolescent rat by diffusion tensor imaging, we revealed that an axonal flow became more anisotropic in the glucocorticoid exposure group. As above, we confirmed that the brain development was affected by the prenatal glucocorticoid exposure.
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Report
(3 results)
Research Products
(12 results)
