Clinicopathological study for differential radiological diagnosis of dementia
| Project/Area Number |
24791232
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Nagoya University (2013-2014)
Juntendo University (2012) |
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Principal Investigator |
FUJISHIRO Hiroshige 名古屋大学, 医学(系)研究科(研究院), 寄附講座講師 (20536924)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | DLB / AD / 早期診断 / レビー病理 / 神経原線維変化 / ブドウ糖代謝 / 神経画像 / レビー小体病 / 脳機能画像 / FDG-PET / 脳血流SPECT / レビー小体 / アミロイド / レビー小体型認知症 / アルツハイマー病 / 神経病理 / 神経基盤 / ドパミン |
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| Outline of Final Research Achievements |
It is extremely challenging to differentially diagnose dementia with Lewy bodies (DLB) from Alzheimer's disease (AD) at predementia stages. Olfactory dysfunction, dysautonomia, and mood and sleep disorders were present in most DLB patients before the onset of memory loss. The presence of prodromal symptoms of Lewy body disease (LBD) or findings of occipital hypometabolism helps us to predict the possible pathophysiological process of LBD in non-demented patients. On the other hand, some hippocampal sparing AD patients exhibited atypical presentation rather than memory loss as initial symptom. Clinicopathological correlations including brain blood perfusion supported the previous findings. The diversity and the long-term nature of prodromal states of neurodegenerative dementing disorders were partially revealed. Further clinicopathological studies including radiological findings will be needed.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Autopsy-confirmed hippocampal-sparing Alzheimer’s disease with delusional jealousy as initial manifestation.2015
Author(s)
Fujishiro H, Iritani S, Hattori M, Sekiguchi H, Matsunaga S, Habuchi C, Torii Y, Umeda K, Ozaki N, Yoshida M, Fujita K.
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Journal Title
Psychogeriatrics
Volume: 15
Issue: 3
Pages: 198-203
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Diagnostic Accuracy of 123I-Meta-Iodobenzylguanidine Myocardial Scintigraphy in Dementia with Lewy Bodies: A Multicenter Study.2015
Author(s)
Yoshita M, Arai H, Arai H, Arai T, Asada T, Fujishiro H, Hanyu H, Iizuka O, Iseki E, Kashihara K, Kosaka K, Maruno H, Mizukami K, Mizuno Y, Mori E, Nakajima K, Nakamura H, Nakano S, Nakashima K, Nishio Y, et al.
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Journal Title
PLoS One
Volume: 10
Issue: 3
Pages: 0-0
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Pathology and temporal onset of visual hallucinations, misperceptions and family misidentification distinguishes Dementia with Lewy bodies from Alzheimer’s disease.2013
Author(s)
Ferman TJ, Arvanitakis Z, Fujishiro H, Duara R, Parfitt F, Purdy M, Waters C, Barker W, Graff-Radford NR, Dickson DW.
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Journal Title
Parkinsonism Relat Disord
Volume: 19
Issue: 2
Pages: 227-231
DOI
Related Report
Peer Reviewed
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[Presentation] Two autopsy cases of minimum nigral degeneration in psychiatric hospital: implication of early stages of dementia with Lewy bodies
Author(s)
Fujishiro H, Habuchi C, Iritani S, Sekiguchi H, Torii Y, Umeda K, Miyata M, Yoshida M, Ozaki O, Fujita K.
Organizer
第20回世界パーキンソン病会議
Place of Presentation
ジュネーブ, スイス
Related Report
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