| Project/Area Number |
24791234
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
|
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| Research Institution | Tokai University (2013)
Tokyo Medical University (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 精巣 / 炭酸リチウム / 精巣内環境 / マウス / 精子形成 |
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| Research Abstract |
Lithium carbonate is used widely bipolar depression and depression as a mood stabilizer in the psychiatric area. Lithium has a very important role in functional regulation of the endocrine and thyroid in vivo. However, the over state of the lithium is spasm of muscle, caused kidney damage and failure to thrive. Recently, it was reported that long-term administration of lithium carbonate was has induced lesion of testicular function in experimental animals after sexual maturity. However, it have never been reported that the administration of lithium carbonate before sexual maturity was affected the development and function of the testes. In this study, it investigate the effect on the development and function of the testes by administrated of lithium carbonate before sexual maturity.
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