Effect of administration of lithium carbonate in the testis of before sexual maturity

• Project/Area Number: 24791234
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Tokai University (2013); Tokyo Medical University (2012)
• Principal Investigator: TERAYAMA Hayato 東海大学, 医学部, 講師 (00384983)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 精巣 / 炭酸リチウム / 精巣内環境 / マウス / 精子形成

Research Abstract

Lithium carbonate is used widely bipolar depression and depression as a mood stabilizer in the psychiatric area. Lithium has a very important role in functional regulation of the endocrine and thyroid in vivo. However, the over state of the lithium is spasm of muscle, caused kidney damage and failure to thrive. Recently, it was reported that long-term administration of lithium carbonate was has induced lesion of testicular function in experimental animals after sexual maturity. However, it have never been reported that the administration of lithium carbonate before sexual maturity was affected the development and function of the testes. In this study, it investigate the effect on the development and function of the testes by administrated of lithium carbonate before sexual maturity.

Research Products

• [Journal Article] Contribution of IL-12/IL-35 common subunit p35 to maintaining the testicular immune privilege (2014)
  • Author(s): Terayama H, Yoshimoto T, Hirai S, Naito M, Qu N, Hatayama N, Hayashi S, Mitobe K, Furusawa J, Mizoguchi I, Kezuka T, Goto H, Suyama K, Moriyama H, Sakabe K, Itoh M.
  • Journal Title: PLoS One Volume: 9 Issue: 4 Pages: e96120-e96120
  • DOI: 10.1371/journal.pone.0096120
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Gross anatomical study of bilateral megaureters associated with renal pelvis dilatation and a giant urinary bladder: an adult cadaver with a brief review of the literature (2013)
  • Author(s): Terayama H, Yi SQ, Hirai S, Qu N, Naito M, Hatayama N, Kawata S, Itoh M
  • Journal Title: Anat Sci Int Volume: 88 Issue: 3 Pages: 171-174
  • DOI: 10.1007/s12565-013-0172-3
  • Peer Reviewed
• [Journal Article] Effects on the local immunity in the testis by exposure to di-(2-ethylhexyl) phthalate (DEHP) in mice (2013)
  • Author(s): Kitaoka M, Hirai S, Terayama H, Naito M, Qu N, Hatayama N, Miyaso H, Matsuno Y, Komiyama M, Itoh M, Mori C
  • Journal Title: J Reprod Dev Volume: 59(5) Pages: 485-90
  • NAID: 130003361051
  • URL: https://www.jstage.jst.go.jp/article/jrd/59/5/59_2012-180/_pdf
  • Peer Reviewed
• [Journal Article] Serum autoantibodies in mice immunized with syngeneic testicular germ cells alone. (2013)
  • Author(s): Hirai S, Naito M, Terayama H, Hatayama N, Qu N, Musha M, Itoh M.
  • Journal Title: Am J Reprod Immunol Volume: 70 Issue: 6 Pages: 509-517
  • DOI: 10.1111/aji.12145
  • Peer Reviewed
• [Journal Article] Pinealectomy in a broiler chicken model impairs endochondral ossification and induces rapid cancellous bone loss. (2013)
  • Author(s): Aota Y, Terayama H, Saito T, Itoh M.
  • Journal Title: Spine J. Volume: 13 Issue: 11 Pages: 1607-1616
  • DOI: 10.1016/j.spinee.2013.05.017
  • Peer Reviewed
• [Journal Article] Proposal for a new classification of variations in the iliac venous system based on internal iliac veins: a case series and a review of double and left inferior vena cava. (2013)
  • Author(s): Hayashi S, Naito M, Hirai S, Terayama H, Miyaki T, Itoh M, Fukuzawa Y, Nakano T.
  • Journal Title: Anat Sci Int Volume: 88 Issue: 4 Pages: 183-188
  • DOI: 10.1007/s12565-013-0182-1
  • NAID: 10031194444
  • Peer Reviewed
• [Journal Article] Anatomical study of superior cluneal nerve entrapment. (2013)
  • Author(s): Kuniya H, Aota Y, Saito T, Kamiya Y, Funakoshi K, Terayama H, Itoh M.
  • Journal Title: J Neurosurg Spine Volume: 19 Issue: 1 Pages: 76-80
  • DOI: 10.3171/2013.4.spine12683
  • Peer Reviewed
• [Journal Article] Epstein‐Barr virus‐Induced gene‐3(EBI3)knockout マウスにおける精巣内免疫微小環境の変化 (2013)
  • Author(s): 寺山隼人, 平井宗一, 曲寧, 内藤宗和, 畑山直之, 林省吾, 善本隆之, 坂部貢, 伊藤正裕
  • Journal Title: Reprod Immunol Biol Volume: 28(1/2) Pages: 19-25
  • NAID: 130004678822
  • URL: http://jglobal.jst.go.jp/public/20090422/201302200071508718
  • Peer Reviewed
• [Journal Article] Effects on the local immunity in the testis by exposure to di-(2-ethylhexyl) phthalate (DEHP) in mice. (2013)
  • Author(s): Kitaoka M, Hirai S, Terayama H, Naito M, Qu N, Hatayama N, Miyaso H, Matsuno Y, Komiyama M, Itoh M, Mori C.
  • Journal Title: J Reprod Dev Volume: 59 Pages: 485-490
  • NAID: 130003361051
  • Peer Reviewed
• [Presentation] 肩こりに対する経穴同時注射の臨床的効果と薬液効果部位について (2014)
  • Author(s): 寺山隼人, 山崎一, 田中理, 隅山香織, 澤田真如, 瓜本言哉, 益田律子, 関口雅樹, 鈴木利保, 坂部貢
  • Organizer: 第119回日本解剖学会総会・全国学術集会
  • Place of Presentation: 自治医大
• [Presentation] 肩こりに対する経穴同時注射の臨床的効果と薬液効果部位について (2014)
  • Author(s): 寺山隼人、山崎一、田中理、隅山香織、澤田真如、瓜本言哉、益田律子、関口雅樹、鈴木利保、坂部貢
  • Organizer: 第11９回日本解剖学会総会・全国学術集会
  • Place of Presentation: 自治医科大学
• [Presentation] Interleukin-35 plays a pivotal role in maintaining the testicular immune privilege (2013)
  • Author(s): Terayama H, Hirai S, Naito M, Yoshimoto T, Hirai S, Qu N, Hatayama N, Suyama K, Skabe K, Itoh M
  • Organizer: privilege.第28回日本生殖免疫学会総会・学術集会
  • Place of Presentation: 武庫川
• [Presentation] フタル酸エステル微量投与による精巣微少環境の変化 (2013)
  • Author(s): 寺山隼人, 倉升三幸, 平井宗一, 内藤宗和, 曲寧, 隅山香織, 伊藤正裕, 坂部貢
  • Organizer: 第20回日本免疫毒性学会学術大会
  • Place of Presentation: 代々木
• [Presentation] 環境毒性物質の低用量曝露による精巣微少環境の変化 (2013)
  • Author(s): 寺山隼人, 伊藤正裕, 平井宗一, 内藤宗和, 曲寧, 倉升三幸, 小川夕輝, 隅山香織, 坂部貢
  • Organizer: 第22回日本臨床環境医学会学術集会
  • Place of Presentation: 白金
• [Presentation] Pathomechanism underlying the onset of scoliosis in a PNX broiler chicken model (2013)
  • Author(s): Aota Y, Terayama H, Saito T, Itoh M
  • Organizer: 10th International Conference on Conservative Management of Spinal Deformities - SOSORT 2013 Annual Meeting
  • Place of Presentation: Chicago
• [Presentation] Testicular immune-microenvironment in the Epstein‐Barr virus‐Induced gene‐3(EBI3) knock out mice (2013)
  • Author(s): Terayama H, Hirai S, Yoshimoto T, Naito M, Qu N, Hatayama N, Skabe K, Itoh M
  • Organizer: The 12th Congress of the International Society for Reproductive Immunology (ISIR)
  • Place of Presentation: Boston
• [Presentation] 精巣とサイトカイン (2013)
  • Author(s): 寺山隼人, 内藤宗和, 曲寧, 平井宗一, 畑山直之, 伊藤正裕
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: 高松
  • Invited
• [Presentation] Testicular immune-microenvironment in the Epstein-Barr virus-Induced gene-3 (EBI3) knock out mice (2013)
  • Author(s): Hayato Terayama, Shuichi Hirai, Takayuki Yoshimoto, Munekazu Naito, Ning Qu , Naoyuki Hatayama, Kou Sakabe, Masahiro Itoh
  • Organizer: The 12th Congress of the International Society for Immunology Reproduction (ISIR)
  • Place of Presentation: Boston
• [Presentation] 環境毒性物質の低用量暴露による精巣微小環境の変化 (2013)
  • Author(s): 寺山隼人、伊藤正裕、平井宗一、内藤宗和、曲寧、北岡三幸、小川夕輝、隅山香織、坂部貢
  • Organizer: 第22回日本臨床環境医学会学術集会
  • Place of Presentation: 北里大学白金キャンパス
• [Presentation] フタル酸エステル微量投与による精巣内免疫微小環境の変化 (2013)
  • Author(s): 寺山隼人、倉升三幸、平井宗一、内藤宗和、曲寧、隅山香織、伊藤正裕、坂部貢
  • Organizer: 第20回日本免疫毒性学会学術大会
  • Place of Presentation: 東海大学代々木キャンパス
• [Presentation] Interleukin-35 plays a pivotal role in maintaining the testicular immune privilege (2013)
  • Author(s): Hayato Terayama, Munekazu Naito, Takayuki Yoshimoto, Shuichi Hirai, Ning Qu, Naoyuki Hatayama, Kaori Suyama, Kou Sakabe, Masahiro Itoh
  • Organizer: 第28回日本生殖免疫学会学術集会
  • Place of Presentation: 兵庫医科大学
• [Presentation] 精巣とサイトカイン (2013)
  • Author(s): 寺山隼人・内藤宗和・曲寧・平井宗一・畑山直之・伊藤正裕
  • Organizer: 日本解剖学会
  • Place of Presentation: サンポートホール高松
  • Invited
• [Presentation] Testicular immune-microenvironment in the Epstein‐Barr virus‐Induced gene‐3(EBI3) knock out mice (2012)
  • Author(s): Terayama H, Hirai S, Qu N, Hatayama N, Hirayanagi Y, Naito M, Yoshimoto T, Itoh M
  • Organizer: 第27回日本生殖免疫学会総会・学術集会
  • Place of Presentation: 高槻
• [Presentation] Role of intratesticular Epstein-Barr Virus-Induced Gene-3 (EBI3) in the mouse (2012)
  • Author(s): Terayama H, Hirai S, Qu N, Hirayanagi Y, Musha M, Naito M, Yoshimoto T, Itoh M
  • Organizer: 第31回日本アンドロロジー学会学術大会
  • Place of Presentation: 神戸
• [Presentation] Role of intratesticular Epstein-Barr Virus-Induced Gene-3 (EBI3) in the mouse (2012)
  • Author(s): Hayato Terayama, Shuichi Hirai, Ning Qu, Yoshie Hirayanagi, Muhetaerjiang Musha, Munekazu Naito, Takayuki Yoshimoto and Masahiro Itoh
  • Organizer: 日本アンドロロジー学会
  • Place of Presentation: 神戸ポートピアホテル
• [Presentation] Testicular immune-microenvironment in the Epstein-Barr virus-Induced gene-3 (EBI3) knock out mice (2012)
  • Author(s): Hayato Terayama, Shuichi Hirai, Ning Qu, Naoyuki Hatayama, Yoshie Hirayanagi, Munekazu Naito, Takayuki Yoshimoto and Masahiro Itoh
  • Organizer: 日本生殖免疫学会
  • Place of Presentation: 大阪医科大学