Associated factors with development of alpha-synucleinopathy from idiopathic rapid eye movement sleep behavior disorder
| Project/Area Number |
24791235
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Tokyo Medical University |
|---|
Principal Investigator |
Sakuma Taeko 東京医科大学, 医学部, 講師 (70419026)
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | レム睡眠行動障害 / REM sleep without atonia / ドーパミンアゴニス / 認知機能 / 脳波 / 周波数 / アルファシヌクレイノパチー / ドーパミンアゴニスト / 錯視 / レビー小体型認知症 / 幻視 / 筋活動の抑制を伴わないレム睡眠 / 国際研究者交流 / オーストリア |
|---|
| Outline of Final Research Achievements |
REM sleep behavior disorder (RBD), characterized by dream enactment behavior and inhibited mustle atonia during REM sleep, has a risk of future development of alpha-synucleinopathy. This study revealed that dopamine agonist was effective on 61.7% of idiopathic RBD and an amount of REM sleep without atonia was associated with the effectiveness. For incidentally detected REM sleep without atonia (RWA) without clinical symptoms (isolated RWA), as high as 14% of individuals with isolated RWA. About 80% of idiopathic RBD patients showed mild cognitive impairment and they also showed decreased fast EEG activity during both wakefulness and REM sleep. Among the patients, slow wave activity during REM sleep was especially associated with cognitive decline.
|
Report
(5 results)
Research Products
(29 results)
-
-
-
-
[Journal Article] Epileptic Seizure Prediction Based on Multivariate Statistical Process Control of Heart Rate Variability Features2015
Author(s)
K. Fujiwara, M. Miyajima, T. Yamakawa, E. Abe, Y. Suzuki, Y. Sawada, M. Kano, T. Maehara, K. Ohta, T. Sasai-Sakuma, T. Sasano, M. Matsuura, and E. Matsushima
-
Journal Title
IEEE Transactions on Biomedical Engineering
Volume: PP(99)
Issue: 6
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
