• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The investigation of pathophysiological synaptic dysfunction and exploration of therapeutic drug in ADHD.

Research Project

Project/Area Number 24791236
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionNippon Medical School

Principal Investigator

SATOH Hiromasa  日本医科大学, 医学部, 助教 (50386744)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsADHD / SHR / 神経伝達 / シナプス
Outline of Final Research Achievements

This study, we examined the effect of dopamine (DA) and noradrenaline (NA) on the GABAergic transmission of layer V pyramidal cells in the medial prefrontal cortex (prelimbic cortex and anterior cingulate cortex; ACC) and Purkinje cells in the cerebellum using ADHD model and control rats. We found that the application of DA caused the enhancement of IPSC amplitude which is larger in control than in ADHD model rats recorded in ACC region. Pharmacological studies revealed that the enhancement is mediated by the activation of D1-like receptors. On the other hand, there were no differences the effect of NA application on IPSC amplitude which recorded in pyramidal and Purkinje cells.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Depolarization-induced depression of inhibitory transmission in cerebellar Purkinje cells2013

    • Author(s)
      Hiromasa Satoh, Lihui Qu, Hidenori Suzuki & Fumihito Saitow
    • Journal Title

      Physiological Reports

      Volume: 1(3) Issue: 3

    • DOI

      10.1002/phy2.61

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Novel form of depolarization-induced depression of GABAergic IPSCs in the Purkinje cells.2014

    • Author(s)
      Hiromasa Satoh, Fumihito Saitow and Hidenori Suzuki
    • Organizer
      第44回米国神経科学会議
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Novel form of depolarization-induced synaptic plasticity of GABAergic transmission in the Purkinje cells2014

    • Author(s)
      Hiromasa Satoh, Fumihito Saitow & Hidenori Suzuki
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi