The investigation of pathophysiological synaptic dysfunction and exploration of therapeutic drug in ADHD.
| Project/Area Number |
24791236
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ADHD / SHR / 神経伝達 / シナプス |
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| Outline of Final Research Achievements |
This study, we examined the effect of dopamine (DA) and noradrenaline (NA) on the GABAergic transmission of layer V pyramidal cells in the medial prefrontal cortex (prelimbic cortex and anterior cingulate cortex; ACC) and Purkinje cells in the cerebellum using ADHD model and control rats. We found that the application of DA caused the enhancement of IPSC amplitude which is larger in control than in ADHD model rats recorded in ACC region. Pharmacological studies revealed that the enhancement is mediated by the activation of D1-like receptors. On the other hand, there were no differences the effect of NA application on IPSC amplitude which recorded in pyramidal and Purkinje cells.
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Report
(4 results)
Research Products
(3 results)
