| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Functional nuclear magnetic resonance image experiments were performed after placebo and NK1 receptor antagonist treatments in healthy adults and then the BOLD activation in nucleus accumbens during a reward task was examined. The activation in nucleus accumbens during the reward anticipation was significantly decreased in NK1 receptor antagonist treatment compared to placebo treatment. Next, we examined the BOLD activation in nucleus accumbens during the reward task in heavy drinkers with a high risk of alcohol dependence. In the heavy drinkers, there was a positive correlation between the BOLD signal change in nucleus accumbens during the reward anticipation and their alcohol consumption. Therefore, focusing on the activation in nucleus accumbens during the reward anticipation associated with alcohol consumption may be beneficial to elucidate the preventive effects of NK1 receptor antagonists on development of alcohol dependence in heavy drinkers.
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