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A clinical application of Near-Infrared Spectroscopy to Modified Electroconvulsive Therapy

Research Project

Project/Area Number 24791242
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionOsaka Medical College

Principal Investigator

TSUTSUMI Atsushi  大阪医科大学, 医学部, 助教 (40388278)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords電気けいれん療法 / 光トポグラフィー / うつ病 / 統合失調症 / 言語流暢性課題 / 治療学的バイオマーカー / 精神科治療の生物学的指標
Research Abstract

One of the controversial points in using ECT is a lack of specific indicator, so biological marker for therapeutic effect which can be applied to ECT is required. As a means of biological indicator, we adopted near-infrared spectroscopy (NIRS) and measured the therapeutic effect of ECT in Depression and Schizophrenia. We completed Hamilton Rating Scale for Depression and Brief Psychiatric Rating Scale for Schizophrenia. Cerebral blood flow was measured by 22-channel NIRS before and after ECT. The correlation between integral value in NIRS and therapeutic effect of ECT was observed in severe endogenous depression and also in schizophrenia underwent maintenance ECT. However, there was no relation observed between the integral value and therapeutic effect in depressive states occurred by secondary disability of other psychiatric disorders.
To demonstrate the consequence of our report, future study employing more sample size should be verified.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (20 results)

All 2014 2013

All Journal Article (13 results) (of which Peer Reviewed: 1 results) Presentation (7 results)

  • [Journal Article] 薬剤性血小板減少症を呈し治療に難渋した双極I型障害の1例2014

    • Author(s)
      村田恵里奈, 井手健太郎, 堤淳, 康純, 米田博
    • Journal Title

      精神神経学雑誌

      Volume: 116 Pages: 88-88

    • Related Report
      2013 Final Research Report
  • [Journal Article] 薬剤性血小板減少症を呈し治療に難渋した双極性I型障害の1例2014

    • Author(s)
      村田恵里奈、井手健太郎、堤淳、川野涼、康純、米田博
    • Journal Title

      精神神経学雑誌

      Volume: 116 Pages: 88-88

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 【非定型精神病の新しい診断基準】生物学的研究への応用2013

    • Author(s)
      金沢徹文, 川野涼, 富樫哲也, 堤淳, 康純, 米田博
    • Journal Title

      最新精神医学

      Volume: 18 Pages: 329-334

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] 【非定型精神病の新しい診断基準】非定型精神病の評価者間一致度の向上に向けて2013

    • Author(s)
      堤淳, 久保洋一郎, 山内繁, 金沢徹文, 康純, 米田博
    • Journal Title

      最新精神医学

      Volume: 18 Pages: 317-323

    • Related Report
      2013 Final Research Report
  • [Journal Article] 行動異常を呈したI型糖尿病の1例2013

    • Author(s)
      丸山惣一郎, 井手健太郎, 堤淳, 川野涼, 康純, 米田博
    • Journal Title

      精神神経学雑誌

      Volume: 115 Pages: 108-109

    • Related Report
      2013 Final Research Report
  • [Journal Article] 抑うつ状態で発症したがECT 施行後認知症が顕在化した1例2013

    • Author(s)
      井手健太郎, 久保田裕子, 塚本琢磨, 久保洋一郎, 金沢徹文, 堤淳, 川野涼, 康純, 米田博
    • Journal Title

      精神神経学雑誌

      Volume: 115 Pages: 106-106

    • Related Report
      2013 Final Research Report
  • [Journal Article] 統合失調症と摂食障害を示した1例2013

    • Author(s)
      今村格, 堤淳, 西口昌樹, 川野涼, 康純, 米田博
    • Journal Title

      精神神経学雑誌

      Volume: 115 Pages: 103-104

    • Related Report
      2013 Final Research Report
  • [Journal Article] Genome-wide associatin study of atypical psychosis.2013

    • Author(s)
      Kanazawa T, Ikeda M, Glatt SJ, Tsutsumi A, Kikuyama H, Kawamura Y, Nishida N, Miyagawa T, Hashimoto R, Takeda M, Sasaki T, Tokunaga K, Koh J, Iwata N, Yoneda H
    • Journal Title

      American Journal of Medical Genetics Part B Neuropschiatric

      Volume: Vol 162 Issue 7 Pages: 679-86

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【非定型精神病の新しい診断基準】非定型精神病の評価者間一致度の向上にむけて2013

    • Author(s)
      堤淳、久保洋一郎、山内繁、金沢徹文、康純、米田博
    • Journal Title

      最新精神医学

      Volume: 18 Pages: 317-323

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 行動異常を呈した1型糖尿病の1例2013

    • Author(s)
      丸山惣一郎、井手健太郎、堤淳、川野涼、康純、米田博
    • Journal Title

      精神神経学雑誌

      Volume: 115 Pages: 108-109

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 抑うつ状態で発症したがECT施行後認知症状が顕在化した1例2013

    • Author(s)
      井手健太郎、久保田祐子、塚本琢磨、久保洋一郎、金沢徹文、堤淳、川野涼、康純、米田博
    • Journal Title

      精神神経学雑誌

      Volume: 115 Pages: 106-106

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 統合失調症症状と摂食障害を示した1例2013

    • Author(s)
      今村格、堤淳、西口昌樹、川野涼、康純、米田博
    • Journal Title

      精神神経学雑誌

      Volume: 115 Pages: 103-104

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Genome-wide association study of atypical psychosis2013

    • Author(s)
      金沢 徹文 他
    • Journal Title

      American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

      Volume: 162 Issue: 7 Pages: 679-686

    • DOI

      10.1002/ajmg.b.32164

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 修正型電気けいれん療法における光トポグラフィ-検査の有用性に関する研究2013

    • Author(s)
      堤 淳
    • Organizer
      日本神経精神医学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] 修正型電気けいれん療法における光トポグラフィ-検査の有用性に関する研究2013

    • Author(s)
      堤 淳
    • Organizer
      日本精神神経学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of CACNA1C rs1006737 on Schizophrenia with prolonged QTc2013

    • Author(s)
      Atsushi Tsutsumi, Takao Kaneko, Hiroyuki Uenishi, Tetsufumi Kanazawa, Jun Koh, Hiroshi Yoneda
    • Organizer
      XXI st World Congress of Psychiatric Genetics
    • Place of Presentation
      BOSTON USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 修正型電気けいれん療法における光トポグラフィー検査の有用性に関する研究2013

    • Author(s)
      堤 淳
    • Organizer
      日本神経精神医学会
    • Place of Presentation
      大阪ライフサイエンスセンター
    • Related Report
      2013 Annual Research Report
  • [Presentation] 修正型電気けいれん療法における光トポグラフィー検査の有用性に関する研究2013

    • Author(s)
      堤 淳
    • Organizer
      日本精神神経学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of CACNA1C rs1006737 on Schizophrenia with prolonged QTc2013

    • Author(s)
      Atsushi Tsutsumi,Takao Kaneko,Hiroyuki Uenishi,Tetsufumi Kanazawa,Jun Koh,Hiroshi Yoneda
    • Organizer
      XXI st World Congress of Psychiatric Genetics
    • Place of Presentation
      BOSTON
    • Related Report
      2013 Annual Research Report
  • [Presentation] 修正型電気けいれん療法における光トポグラフィ―検査の有用性に関する検討2013

    • Author(s)
      堤 淳
    • Organizer
      第109回日本精神神経学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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