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Role of PDEs in antidepressant effects in the hippocampal dentate gyrus.

Research Project

Project/Area Number 24791244
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionKurume University

Principal Investigator

KUROIWA Mahomi  久留米大学, 医学部, 助教 (20585690)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords抗うつ薬 / 海馬歯状回 / ホスホジエステラーゼ / ドーパミン / 歯状回 / DARPP-32 / ドーパミンD1受容体
Research Abstract

Recent studies show that chronic SSRI treatment induces novel effects such as increase of the exitability of mature granule cells and expression of dopamine D1 receptors in the dentate gyrus (DG), called dematuration. Here, we investigated the role of PDEs in antidepressant effects, because inhibition of PDE results in increase of D1 receptor signaling. In this study, we revealed that PDE2 and PDE4 modulate the level of D1 receptor signaling in the DG. Combined treatment with fluoxetine and PDE2 and/or PDE4 inhibitors significantly enhanced D1 signaling induced by fluoxetine. These biochemical actions of PDE2 and PDE4 inhibitors may contribute to the development of new antidepressants.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (7 results)

  • [Journal Article] Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.2013

    • Author(s)
      Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
    • Journal Title

      Neuropsychopharmacology

      Volume: 38(8) Issue: 8 Pages: 1409-25

    • DOI

      10.1038/npp.2013.38

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute effects of resveratrol to enhance cocaine-induced dopamine neurotransmission in the striatum.2013

    • Author(s)
      Takahide Shuto
    • Journal Title

      Neuroscience Letters

      Volume: 542 Pages: 107-112

    • DOI

      10.1016/j.neulet.2013.02.050

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons.2012

    • Author(s)
      Kuroiwa Mahomi
    • Journal Title

      Neuropharmacology

      Volume: 7 Issue: 7 Pages: 1248-1257

    • DOI

      10.1016/j.neuropharm.2012.07.046

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 抗うつ薬による海馬歯状回顆粒細胞の形態変化 : FIB/SEM を用いた樹状突起の3D電顕解析2014

    • Author(s)
      北原 陽介, 太田 啓介, 首藤 隆秀, 黒岩 真帆美, 外角 直樹, 蓮尾 博, 都合 亜記暢, 中村 桂一郎, 西 昭徳
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      東北大学百年記念会館川内萩ホール, 川内国際センター
    • Year and Date
      2014-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 抗うつ薬による海馬歯状回顆粒細胞の形態変化:FIB/SEMを用いた樹状突起の3D電顕解析2014

    • Author(s)
      北原 陽介、太田 啓介、首藤 隆秀、黒岩 真帆美、外角 直樹、蓮尾 博、都合 亜記暢、中村 桂一郎、西 昭徳
    • Organizer
      薬理学会年会
    • Place of Presentation
      東北大学百周年記念会館川内萩ホール、仙台国際センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] 線条体におけるムスカリン受容体を介したDARPP-32 リン酸化調節2013

    • Author(s)
      黒岩 真帆美, 浜田 美保, 稗田 恵理子, 首藤 隆秀, 外角 直樹, 西 昭徳
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2013-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] コカインで増強される線条体ドーパミン情報伝達に対するレスベラトロールの急性薬理作用2013

    • Author(s)
      首藤 隆秀, 黒岩 真帆美, 古賀 夕貴, 河原 幸江, 外角 直樹, 西 昭徳
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2013-03-21
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 線条体におけるムスカリン受容体を介したDARPP-32リン酸化調節2013

    • Author(s)
      黒岩 真帆美、浜田 美保、稗田 恵理子、首藤 隆秀、外角 直樹、西 昭徳
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] コカインにより活性化される線条体ドーパミン神経伝達に対するレスベラトロールの急性作用2012

    • Author(s)
      首藤 隆秀, 黒岩 真帆美, 古賀 夕貴, 西 昭徳
    • Organizer
      第65回日本薬理学会西南部会
    • Place of Presentation
      熊本大学薬学部
    • Year and Date
      2012-11-23
    • Related Report
      2013 Final Research Report
  • [Presentation] コカインにより活性化される線条体ドーパミン神経伝達に対するレスベラトロールの 急性作用

    • Author(s)
      首藤 隆秀、黒岩 真帆美、古賀 夕貴、西 昭徳
    • Organizer
      第65回日本薬理学会西南部会
    • Place of Presentation
      熊本大学薬学部
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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