What is a key of the restoration success of schizophrenia.

• Project/Area Number: 24791246
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: HORI Hikaru 産業医科大学, 医学部, 助教 (50421334)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 統合失調症 / 認知機能 / 復職 / 社会機能 / BDNF / バイオロジカルマーカー / 臨床 / 統合失調症4 / 就労 / 復職成功率

Outline of Final Research Achievements

The employment rate and the income of patients with schizophrenia are very low. Cognitive dysfunction is considered a core feature of the disease because it significantly affects patients’ social and occupational functioning. We divided the subjects into a successful return to work group (SRWG) and failure return to work group (FRWG). Patients in the FRGW had lower cognitive function and higher negative symptoms scores than those in the SRWG. The role of BDNF in schizophrenia of symptoms and cognitive function was investigated. This study showed that schizophrenia patients had significantly lower levels of BDNF than healthy subjects, and positive correlated with BDNF levels and cognitive scores in schizophrenia.
Our study investigating the effectiveness of switching from antipsychotic polypharmacy to monotherapy showed that the patients who switched to monotherapy showed greater improvement on measure of attention and processing speed compared with who continued with polypharmacy.

Research Products

• [Journal Article] Current Pharmacotherapy Strategies and Considerations for the Cognitive Dysfunction Associated with Schizophrenia: A Mini Review (2015)
  • Author(s): Hori H, Yoshimura R, Katsuki A, Atake K, Nakamura J.
  • Journal Title: International Journal of Neurology and Neurotherapy Volume: 2 Pages: 1-3
  • Peer Reviewed / Open Access
• [Journal Article] No significant association between brain-derived neurotrophic factor gene rs6265 and cognitive function in Japanese patients with schizophrenia. (2014)
  • Author(s): Kishi T, Fukuo Y, Moriwaki M, Iwata N, Hori H, Yoshimura R, Katsuki A, Ikenouchi-Sugita A, Atake K, Umene-Nakano W, Nakamura J, Kaneda Y, Fujita K.
  • Journal Title: Psychiatry Research Volume: 215(3) Pages: 803-805
  • Peer Reviewed
• [Journal Article] Effect of blonanserin on cognitive and social function in acute phase Japanese schizophrenia compared with risperidone. (2014)
  • Author(s): Hori H, Yamada K, Kamada D, Shibata Y, Katsuki A, Yoshimura R, Nakamura J.
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: 10 Pages: 527-533
  • DOI: 10.2147/ndt.s59861
  • Peer Reviewed / Open Access
• [Journal Article] Relationships between brain-derived neurotrophic factor, clinical symptoms, and decision-making in chronic schizophrenia: data from the Iowa Gambling Task. (2014)
  • Author(s): Hori H, Yoshimura R, Katsuki A, Atake K, Nakamura J.
  • Journal Title: Frontiers in Behavioural Neurosciences Volume: 8 Pages: 1-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 認知機能障害を考慮した統合失調症患者への薬物療法を考える～就労を見据えた薬物治療戦略～ (2014)
  • Author(s): 堀輝、香月あすか、西井重超、柴田裕香、菅健太郎、中村純
  • Journal Title: 臨床精神薬理 Volume: 17(5) Pages: 665-671
• [Journal Article] Switching to antipsychotic monotherapy can improve attention and (2013)
  • Author(s): Hikaru Hori, Reiji Yoshimura, Asuka Katsuki, Atsuko-Ikenouchi Sugita, Kiyokazu Atake,
  • Journal Title: Journal of psychiatric research Volume: 47 Issue: 12 Pages: 1843-1848
  • DOI: 10.1016/j.jpsychires.2013.08.024
  • Peer Reviewed
• [Presentation] Swtiching to antipsychotic monotherapy can improve attention and social activity in chronic schizophrenia patients: a randomized controlled study. (2014)
  • Author(s): Hori H, Yoshimura R, Katsuki A, Atake K, Nakamura J
  • Organizer: 29th CINP Congress
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-06-22 – 2014-06-26
• [Presentation] 抗精神病薬の多剤併用療法を単剤治療への切り替えによる、精神症状、認知機能及び血液検査データに対する影響 (2014)
  • Author(s): 堀 輝、香月 あすか、阿竹 聖和、杉田 篤子、吉村玲児、中村 純
  • Organizer: 第9回日本統合失調症学会
  • Place of Presentation: 京都テルサ （京都市南区東九条下殿田町７０）
• [Presentation] Effect of risperidone or blonanserin on cognitive function and psychotic symptoms in patients with acute phase schizophrenia (2013)
  • Author(s): Hikaru Hori, Kenji Yamada, Dan Kamada, Yuka Shibata, Asuka Katsuki, Jun Nakamura
  • Organizer: 26th ECNP
  • Place of Presentation: バルセロナ（Palau de Congressos de Catalunya)