What is a key of the restoration success of schizophrenia.
| Project/Area Number |
24791246
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
HORI Hikaru 産業医科大学, 医学部, 助教 (50421334)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 統合失調症 / 認知機能 / 復職 / 社会機能 / BDNF / バイオロジカルマーカー / 臨床 / 統合失調症4 / 就労 / 復職成功率 |
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| Outline of Final Research Achievements |
The employment rate and the income of patients with schizophrenia are very low. Cognitive dysfunction is considered a core feature of the disease because it significantly affects patients’ social and occupational functioning. We divided the subjects into a successful return to work group (SRWG) and failure return to work group (FRWG). Patients in the FRGW had lower cognitive function and higher negative symptoms scores than those in the SRWG. The role of BDNF in schizophrenia of symptoms and cognitive function was investigated. This study showed that schizophrenia patients had significantly lower levels of BDNF than healthy subjects, and positive correlated with BDNF levels and cognitive scores in schizophrenia.
Our study investigating the effectiveness of switching from antipsychotic polypharmacy to monotherapy showed that the patients who switched to monotherapy showed greater improvement on measure of attention and processing speed compared with who continued with polypharmacy.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] No significant association between brain-derived neurotrophic factor gene rs6265 and cognitive function in Japanese patients with schizophrenia.2014
Author(s)
Kishi T, Fukuo Y, Moriwaki M, Iwata N, Hori H, Yoshimura R, Katsuki A, Ikenouchi-Sugita A, Atake K, Umene-Nakano W, Nakamura J, Kaneda Y, Fujita K.
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Journal Title
Psychiatry Research
Volume: 215(3)
Pages: 803-805
Related Report
Peer Reviewed
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