Elucidation of the dysfunction of the paraventricular nucleus of the thalamus with bipolar disorder model mouse

• Project/Area Number: 24791247
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: KATO Tomoaki 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (40598439)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 精神疾患 / 気分障害 / ミトコンドリア

Research Abstract

We previously generated transgenic mice that express mutant form of mitochondrial DNA (mtDNA) polymerase in their forebrain neurons. These mice showed bipolar disorder-like phenotype and accumulated deleted mitochondrial DNA in the several brain regions including the paraventricular nucleus of the thalamus (PVT). To clarify the characteristic features of the PVT, we performed gene expression analysis of the PVT and other brain regions which have been suggested the involvement in bipolar disorder by using microarray. As a result, we found that the genes related to mitochondrial function, especially oxidative phosphorylation, and cholesterol biosynthesis were highly expressed in the PVT compared with the other brain regions.

Research Products

• [Presentation] Mitochondrial dysfunction in mouse brain causes depression-like behavior and HPA axis dysregulation (2013)
  • Author(s): Kato, TM., Kubota-Sakashita, M., Kasahara, T., Kato, T
  • Organizer: FENS Featured Regional Meeting Neuroscience in Prague
  • Place of Presentation: Czech Republic
• [Presentation] Gene expression analysis of mood disorder model mice expressing mutant form of mitochondrial DNA polymerase in the forebrain (2013)
  • Author(s): Kato, TM., Komori, A., Kubota-Sakashita, M., Kasahara, T., Kato, T
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館
• [Presentation] Mitochondrial dysfunction in mouse brain causes depression-like behavior and HPA axis dysregulation (2013)
  • Author(s): Kato, TM., Kubota-Sakashita, M., Kasahara, T., Kato, T.
  • Organizer: FENS Featured Regional Meeting Neuroscience in Prague
  • Place of Presentation: Prague Congress Centre、チェコ共和国
• [Presentation] Gene expression analysis of mood disorder model mice expressing mutant form of mitochondrial DNA polymerase in the forebrain (2013)
  • Author(s): Kato, TM., Komori, A., Kubota-Sakashita, M., Kasahara, T., Kato, T。
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館,京都府
• [Presentation] Overexpression of mutant form of mitochondrial DNA polymerase in forebrain modulates gene expression in the paraventricular nucleus of the thalamus and leads to recurrent depression-like episodes accompanied by HPA axis dysregulation (2012)
  • Author(s): Kato, TM., Komori, A., Kubota-Sakashita, M., Kasahara, T., Kato, T
  • Organizer: Society for Neuroscience 2012 in New Orleans
  • Place of Presentation: USA
• [Presentation] Mood disorders model mice that express mutant form of mitochondrial DNA polymerase show changes in genes regulating HPA axis in the paraventricular nucleus of the thalamus and recurrent depression-like symptom.
  • Author(s): Tomoaki M Kato
  • Organizer: Neuroscience 2012
  • Place of Presentation: アメリカ合衆国、ニューオリンズ
• [Presentation] 変異型ミトコンドリアDNA合成酵素を前脳で発現する気分障害モデルマウスの遺伝子発現解析
  • Author(s): 加藤 智朗
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 国立京都国際会館